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MONNA 目录号 GC18358

规格 价格 库存 购买数量
1mg
¥325.00
现货
5mg
¥1,222.00
现货
10mg
¥1,794.00
现货
25mg
¥4,069.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1572936-83-4 SDF Download SDF
别名 N/A
化学名 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Canonical SMILES COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=CC=CC=C31
分子式 C18H14N2O5 分子量 338.3
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: slightly soluble 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 uM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 uM. MONNA (10 uM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.