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MLS-573151 Sale

(Synonyms: MLS000573151) 目录号 : GC13096

A specific inhibitor of Cdc42

MLS-573151 Chemical Structure

Cas No.:10179-57-4

规格 价格 库存 购买数量
5 mg
¥900.00
现货
10 mg
¥1,530.00
现货
25 mg
¥3,150.00
现货
50 mg
¥4,950.00
现货
100 mg
¥8,550.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

MLS-573151 is a specific and cell permeable inhibitor of Cdc42 [1].

Cdc42 is a small GTPase of the Rho family involved in regulating signaling pathways that control diverse cellular functions such as cell morphology, cell migration, cell cycle progression and endocytosis [2].

In vitro: MLS-573151 was a specific, cell permeable inhibitor of Cdc42 with an IC50 of 2 μM [1]. MLS-573151 showed no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. MLS-573151 functioned by blocking the binding of GTP to Cdc42 [1]. In marrow-derived mesenchymal stem cells, MLS-573151 showed no effect on cell migration [3].

References:
[1] Surviladze Z, Waller A, Wu Y, et al.  Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay[J]. Journal of biomolecular screening, 2010, 15(1): 10-20.
[2] Qadir M I, Parveen A, Ali M.  Cdc42: Role in Cancer Management[J]. Chemical biology & drug design, 2015, 86(4): 432-439.
[3] Wang L, Yang L, Tian L, et al.  Cannabinoid Receptor 1 Mediates Homing of Bone Marrow‐Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury[J]. Journal of cellular physiology, 2017, 232(1): 110-121.

Chemical Properties

Cas No. 10179-57-4 SDF
别名 MLS000573151
化学名 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-benzenesulfonamide
Canonical SMILES NS(C(C=C1)=CC=C1N2C(C3=CC=CC=C3)CC(C4=CC=CC=C4)=N2)(=O)=O
分子式 C21H19N3O2S 分子量 377.5
溶解度 ≤20mg/ml in DMSO;30mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.649 mL 13.245 mL 26.4901 mL
5 mM 0.5298 mL 2.649 mL 5.298 mL
10 mM 0.2649 mL 1.3245 mL 2.649 mL
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