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Mevalonate (lithium salt) Sale

(Synonyms: Mevalonic Acid, MVA, Pentanoic Acid) 目录号 : GC52250

An intermediate in the mevalonate pathway

Mevalonate (lithium salt) Chemical Structure

Cas No.:2618458-93-6

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500 μg
¥406.00
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1 mg
¥686.00
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5 mg
¥2,436.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Mevalonate is an intermediate in the mevalonate pathway of cholesterol synthesis.1 It inhibits cell death induced by the HMG-CoA reductase inhibitor simvastatin in C2C12 myoblasts when used at concentrations ranging from 80 to 110 µM.2 Mevalonate (500 µM) reverses decreases in proliferation induced by the HMG-CoA reductase inhibitor lovastatin in several colon cancer cell lines, including RKO and SW480 cells.3 It increases lovastatin-induced decreases in the expression of the genes encoding Axin2, ectodermal-neural cortex 1 (ENC1), BCL2-like 1 (BCL2-L1), and cyclin D1 when used at a concentration of 500 µM. Mevalonate (50 µM) increases Rac1 protein levels, as well as increases Rac1 farnesylation induced by the arachidonic metabolite 15(S)-HETE in human dermal microvascular endothelial cells (HDMVECs).4

1.Yazawa, H., Zimmermann, B., Asami, Y., et al.Simvastatin promotes cell metabolism, proliferation, and osteoblastic differentiation in human periodontal ligament cellsJ. Periodontol.76(2)295-302(2005) 2.Moschetti, A., Dagda, R.K., and Ryan, R.O.Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubesNanomedicine37102439(2021) 3.Gong, L., Xiao, Y., Xia, F., et al.The mevalonate coordinates energy input and cell proliferationCell Death Dis.10(4)327(2019) 4.Singh, N.K., Kundumani-Sridharan, V., and Rao, G.N.12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylationBlood118(20)5701-5712(2011)

Chemical Properties

Cas No. 2618458-93-6 SDF Download SDF
别名 Mevalonic Acid, MVA, Pentanoic Acid
Canonical SMILES O=C(CC(O)(CCO)C)O.[Li]
分子式 C6H11LiO4 分子量 154.09
溶解度 DMSO: soluble 储存条件 Store at 2-8°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 6.4897 mL 32.4486 mL 64.8971 mL
5 mM 1.2979 mL 6.4897 mL 12.9794 mL
10 mM 0.649 mL 3.2449 mL 6.4897 mL
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