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Methylchloroisothiazolinone/Methylisothiazolinone Mixture Sale

(Synonyms: CMIT/MIT, MCI/MI, MCIT/MIT) 目录号 : GC48857

A mixture of isothiazolinone biocides

Methylchloroisothiazolinone/Methylisothiazolinone Mixture Chemical Structure

Cas No.:55965-84-9

规格 价格 库存 购买数量
5mL
¥549.00
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10mL
¥981.00
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25mL
¥2,063.00
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100mL
¥4,940.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2 It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively.2 MCIT/MIT can elicit contact sensitization.3 Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products.

1.Frenzel, E., Schmidt, S., Niederweis, M., et al.Importance of porins for biocide efficacy against Mycobacterium smegmatisApplied and Environmental Microbiology77(9)3068-3073(2011) 2.Lundov, M.D., Johansen, J.D., Zachariae, C., et al.Low-level efficacy of cosmetic preservativesInt. J. Cosmet. Sci.33(2)190-196(2011) 3.Scherrer, M.A.R., and Rocha, V.B.Increasing trend of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI)An. Bras. Dermatol.89(3)527-528(2014)

Chemical Properties

Cas No. 55965-84-9 SDF
别名 CMIT/MIT, MCI/MI, MCIT/MIT
Canonical SMILES CN(SC(Cl)=C1)C1=O.CN(SC=C2)C2=O
分子式 C4H5NOS•C4H4ClNOS 分子量 264.7
溶解度 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.7779 mL 18.8893 mL 37.7786 mL
5 mM 0.7556 mL 3.7779 mL 7.5557 mL
10 mM 0.3778 mL 1.8889 mL 3.7779 mL
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Research Update

Non-fragrance allergens in specific cosmetic products

Contact Dermatitis 2011 Nov;65(5):276-85.PMID:21951136DOI:10.1111/j.1600-0536.2011.01968.x.

Objectives: Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce. Methods: Between January 2000 and December 2010, the specific cosmetic products having caused allergic contact dermatitis, as well as the individual allergenic cosmetic ingredients present in them, were recorded by use of a standardized form. Results: Among 11 different categories of cosmetic product, skin care products, followed by hair care and body-cleansing products, were most often involved. The presence of the allergenic ingredient(s) in a specific cosmetic product was confirmed according to the ingredient label in 959 of 1448 records. Six hundred and twenty-one of 959 concerned non-fragrance components, preservatives being responsible for 58% of them. Reactions to formaldehyde and formaldehyde-releasers were most often correlated with body-cleansing products, particularly 2-bromo-2-nitropropane-1,3-diol and skin care products. They were followed by the Methylchloroisothiazolinone/Methylisothiazolinone Mixture, most frequently found as allergens in hair care and intimate hygiene products, and facial cleansers (in the last category together with diazolidinyl urea). Octocrylene was by far the most frequent (photo)allergen in sun care products. Conclusions: This study provides information on the presence and frequency of allergens in specific causal cosmetic products.