Methimazole D3

Methimazole-d₃ is intended for use as an internal standard for the quantification of methimazole by GC- or LC-MS. Methimazole is an inhibitor of thyroid hormone synthesis.^1,2 It is a substrate for thyroid peroxidase that traps oxidized iodide, preventing its use by thyroglobulin for thyroid hormone synthesis. Methimazole (0.4 mg/kg) inhibits the absorption of radiolabeled iodide by the thyroid gland in rats by 80.9%.³ It reduces the incidence of lymphocytic thyroiditis in the insulin-dependent type 1 diabetic BB/W rat.⁴ Methimazole has been used to induce hypothyroidism in mice.^5,6 Formulations containing methimazole have been used in the treatment of hyperthyroidism.

1.Davidson, B., Soodak, M., Neary, J.T., et al.The irreversible inactivation of thyroid peroxidase by methylmercaptoimidazole, thiouracil, and propylthiouracil in vitro and its relationship to in vivo findingsEndocrinology103(3)871-872(1978) 2.Cooper, D.S.Antithyroid drugsN. Engl. J. Med.352(9)905-917(2005) 3.Brock, R.E., and Head, W.F., Jr.Mechanisms of antithyroidal activity of methimazoleJ. Pharm. Sci.55(8)822-825(1966) 4.Allen, E.M., Rajatanavin, R., Nogimori, T., et al.The effect of methimazole on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W ratAm. J. Med. Sci.292(5)267-271(1986) 5.Bortolotto, V.C., Pinheiro, F.C., Araujo, S.M., et al.Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamineEur. J. Pharmacol.82278-84(2018) 6.Bortolotto, V.C., Araujo, S.M., Pinheiro, F.C., et al.Modulation of glutamate levels and Na+,K+-ATPase activity contributes to the chrysin memory recovery in hypothyroidism micePhysiol. Behav.222112892(2020)