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Methicillin (sodium salt)

目录号 GC10917

Semisynthetic penicillin antibiotic

规格 价格 库存 购买数量
25mg
¥432.00
现货
50mg
¥770.00
现货
100mg
¥1,283.00
现货
250mg
¥2,336.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Methicillin is a semisynthetic penicillin antibiotic.

In vitro: Similar to other β-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. Meticillin can block the cross-linkage between the linear peptidoglycan polymer chains by binding to and competitively inhibiting the transpeptidase enzyme or penicillin-binding proteins [1].

In vivo: In a previous animal study, the treatment with methicillin or gentamicin or both was started 3 days after infection to a experimental mouse model of foreign body infection. Results found that the treatment showed a significant effect, demonstrated as reduction of bacteria on the foreign body, for all three regimens with a reduction of up to 2 log units, but there was no synergism. However, the actual efficacy of the treatment was poor, though the local methicillin concentrations was greater than the MIC for at least 72 h [2].

Clinical trial: Meticillin was developed by Beecham in 1959 and it has been previously used to treat infections caused by susceptible gram-positive bacteria, particularly, penicillinase-producing organisms such as Staphylococcus aureus resistant to most penicillins. However, currently meticillin is no longer manufactured since the more stable and similar penicillins such as oxacillin, flucloxacillin, and dicloxacillin are identified [1].

References:
[1] https://en. wikipedia.org/wiki/Meticillin
[2] Espersen F, Frimodt-M ller N, Corneliussen L, Riber U, Rosdahl VT, Skinh j P.  Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection. Antimicrob Agents Chemother. 1994 Sep;38(9):2047-53.

Chemical Properties

Cas No. 132-92-3 SDF
别名 BRL 1241,SQ 16,123,X 1497
化学名 (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt
Canonical SMILES O=C(N[C@@H]1C(N2[C@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O)C3=C(OC)C=CC=C3OC.[Na+]
分子式 C17H19N2O6S • Na 分子量 402.4
溶解度 ≥ 14.4mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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