Malonyl Coenzyme A (lithium salt)
(Synonyms: 丙二酰辅酶A锂盐,Malonyl-CoA) 目录号 : GC19431A substrate for fatty acid synthase
Cas No.:108347-84-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Malonyl coenzyme A is a coenzyme A derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.1,2 Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA 1 Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.3 Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.2,4
Reference
1. Hiltunen, J.K., Autio, K.J., Schonauer, M.S., et al. Mitochondrial fatty acid synthesis and respiration Biochim.Biophys.Acta. 1797(6-7), 1195-1202 (2010).
2. Summers, R.G., Ali, A., Shen, B., et al. Malonyl-coenzyme A:Acyl carrier protein acyltransferase of Streptomyces glaucescens: A possible link between fatty acid and polyketide biosynthesis Biochem. 34(29), 9389-9402 (1995).
3. Pizer, E.S., Thupari, J., Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts Cancer Research 60, 213-218 (2000).
4. Zhan, J. Biosynthesis of bacterial aromatic polyketides Current Topics in Medicinal Chemistry 9(17), 1598-1610 (2009).
| Cas No. | 108347-84-8 | SDF | |
| 别名 | 丙二酰辅酶A锂盐,Malonyl-CoA | ||
| 化学名 | S-(hydrogen propanedioate) coenzyme A, lithium salt | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(O)=O)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Li] | ||
| 分子式 | C24H38N7O19P3S • XLi | 分子量 | 860.5 |
| 溶解度 | PBS (pH 7.2): 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1621 mL | 5.8106 mL | 11.6212 mL |
| 5 mM | 0.2324 mL | 1.1621 mL | 2.3242 mL |
| 10 mM | 0.1162 mL | 0.5811 mL | 1.1621 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。