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Maduramicin (ammonium salt) Sale

(Synonyms: 马杜霉素铵盐,Maduramycin ammonium) 目录号 : GC49208

A polyether ionophore antibiotic

Maduramicin (ammonium salt) Chemical Structure

Cas No.:84878-61-5

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50 mg
¥770.00
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100 mg
¥1,318.00
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250 mg
¥3,084.00
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500 mg
¥5,791.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Maduramicin is a polyether ionophore antibiotic that has been found in Nocardia.1 It selectively binds to potassium, rubidium, sodium, lithium, and cesium ions over divalent cations. Maduramicin is active against Gram-positive bacteria (MICs = 0.9-125 µg/ml) but not Gram-negative bacteria (MICs = >1,000 µg/ml) or fungi (MICs = 250->1,000 µg/ml). It reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively) and reduces P. berghei transmission in a mouse model of malaria when administered at doses of 4 and 8 mg/kg.2 Maduramicin (5-10 ppm in the diet) reduces the severity of lesions and completely protects chicks against mortality in a model of coccidiosis induced by E. tenella.1 Formulations containing maduramicin have been used in the treatment of coccidiosis in chickens.

1.Liu, C.-M., Hermann, T.E., Downey, A., et al.Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing cultureJ. Antibiot. (Tokyo)36(4)343-350(1983) 2.Maron, M.I., Magle, C.T., Czeny, B., et al.Maduramicin rapidly eliminates malaria parasites and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050Antimicrob. Agents Chemother.60(3)1492-1499(2015)

Chemical Properties

Cas No. 84878-61-5 SDF
别名 马杜霉素铵盐,Maduramycin ammonium
Canonical SMILES [H][C@](O1)([C@@]2([H])O[C@@](O)(C)[C@H](C)C[C@@H]2C)C[C@H](O[C@@H]3C[C@H](OC)[C@@H](OC)[C@H](C)O3)[C@]1([H])[C@@](CC4)(C)O[C@@]4([H])[C@@](CC5)(C)O[C@@]65O[C@@]([C@@H](C)[C@]7([H])O[C@@](CC([O-])=O)(O)[C@@H](C)[C@H](OC)[C@H]7OC)([H])[C@H](C)[C@@H](O)C6.[NH4+]
分子式 C47H79O17·NH4 分子量 934.2
溶解度 DMF: 1 mg/ml 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 1.0704 mL 5.3522 mL 10.7043 mL
5 mM 0.2141 mL 1.0704 mL 2.1409 mL
10 mM 0.107 mL 0.5352 mL 1.0704 mL
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Research Update

Chemistry of Maduramicin. II. Decarboxylation, abnormal ketalization and dehydration

J Antibiot (Tokyo) 1986 Nov;39(11):1541-50.PMID:3793623DOI:10.7164/antibiotics.39.1541.

The behavior of the free acid and ammonium salt of Maduramicin towards heat and alcohols is examined. In refluxing lower alcohols the free acid material is decarboxylated. In addition a bisketal decarboxylated compound as well as an A-ring monoketal decarboxylated derivative are formed. Heating the ammonium salt of the ionophores in suspension in water, or dissolved in inert solvents such as heptane or xylene can cause decarboxylation as well as concomitant dehydration of the F-ring. Reaction of dansyl chloride with the free acid of Maduramicin can cause dehydration of the B-ring under very mild conditions.

Validation of a liquid chromatography-electrospray ionization tandem mass spectrometric method to determine six polyether ionophores in raw, UHT, pasteurized and powdered milk

Food Chem 2016 Apr 1;196:130-7.PMID:26593474DOI:10.1016/j.foodchem.2015.09.011.

This study aimed to validate a method developed for the determination of six antibiotics from the polyether ionophore class (lasalocid, Maduramicin, monensin, narasin, salinomycin and semduramicin) at residue levels in raw, UHT, pasteurized and powdered milk using QuEChERS extraction and high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS). The validation was conducted under an in-house laboratory protocol that is primarily based on 2002/657/EC Decision, but takes in account the variability of matrix sources. Overall recoveries between 93% and 113% with relative standard deviations up to 16% were obtained under intermediate precision conditions. CCα calculated values did not exceed 20% the Maximum Residue Limit for monensin and 25% the Maximum Levels for all other substances. The method showed to be simple, fast and suitable for verifying the compliance of raw and processed milk samples regarding the limits recommended by Codex Alimentarius and those adopted in European Community for polyether ionophores.