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Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) Sale

目录号 : GC47586

An LSD1 inhibitor

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) Chemical Structure

Cas No.:1234494-75-7

规格 价格 库存 购买数量
1 mg
¥616.00
现货
5 mg
¥1,696.00
现货
10 mg
¥2,775.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2 LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 µM.1 It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2 LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.

1.Sharma, S.K., Wu, Y., Steinbergs, N., et al.(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulatorsJ. Med. Chem.53(14)5197-5212(2010) 2.Huang, Y., Greene, E., Murray Stewart, T., et al.Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genesProc. Natl. Acad. Sci. U.S.A.104(19)8023-8028(2007)

Chemical Properties

Cas No. 1234494-75-7 SDF
Canonical SMILES CN/C(NCCCNCCCNCCCN/C(NC)=N/C)=N\C
分子式 C15H36N8.4HCl 分子量 474.3
溶解度 DMSO: soluble,Water: 50 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1084 mL 10.5419 mL 21.0837 mL
5 mM 0.4217 mL 2.1084 mL 4.2167 mL
10 mM 0.2108 mL 1.0542 mL 2.1084 mL
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