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LHW090-A7 Sale

目录号 : GC14141

An inhibitor of NEP

LHW090-A7 Chemical Structure

规格 价格 库存 购买数量
5mg
¥1,176.00
现货
10mg
¥2,037.00
现货
25mg
¥4,305.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

LHW090-A7 is a potential inhibitor of neutral endopeptidase (NEP). It has been shown that the NEP inhibitors induced the increase of plasma levels of endogenous atrial natriuretic peptides (NPs), which makes the inhibition of NEP to be a potential novel therapeutic approach.

NPs block the activity of the renin-angiotensin-aldosterone system, have antihypertrophic and antiproliferative effects, and reduce sympathetic drive. Additionally, NEP inhibitors are expected to trigger natriuretic and diuretic effects. NEP, a zinc-dependent, membrane-bound endopeptidase, hydrolyses peptides on the amino side of hydrophobic residues. It is essential for the processing and catabolism of vasoactive peptides as well as peptides involved in natriuresis and diuresis. NEP is indirectly and directly involved in the regulation of signaling pathways. NEP is implicated in proteolytic degradation or activation of bioactive peptides, growth factors, and cytokines in an indirect fashion. In addition to this, NEP is involved in regulating signaling pathways in a direct manner [1].

In vitro: Up to now, in vitro study of LHW090-A7 is still in the development stage.

In vivo: Up to now, in vivo study of LHW090-A7 is still in the development stage.

Reference:
[1].  Mangiafico, S., Costello-Boerrigter, L., Andersen, I., Cataliotti, A., & Burnett, J. Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics. European Heart Journal. 2012;34(12): 886-893.

Chemical Properties

Cas No. SDF
化学名 (αS)-3'-chloro-α-[[(1S)-2-ethoxy-1-methyl-2-oxoethyl]amino]-[1,1'-biphenyl]-4-propanoic acid, monosodium salt
Canonical SMILES ClC1=CC=CC(C2=CC=C(C[C@H](N[C@H](C(OCC)=O)C)C([O-])=O)C=C2)=C1.[Na+]
分子式 C20H21ClNO4 • Na 分子量 397.8
溶解度 ≤1mg/ml in DMSO;5mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5138 mL 12.5691 mL 25.1383 mL
5 mM 0.5028 mL 2.5138 mL 5.0277 mL
10 mM 0.2514 mL 1.2569 mL 2.5138 mL
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