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Levetiracetam Sale

(Synonyms: 左乙拉西坦; UCB L059) 目录号 : GC17779

An antiepileptic compound

Levetiracetam Chemical Structure

Cas No.:102767-28-2

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥588.00
现货
5mg
¥357.00
现货
100mg
¥746.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Levetiracetam (LEV) is a newly developed antiepileptic drug (AED) with a broad spectrum of efficacy against partial and generalized seizures. [1]

The mode of action of LEV seems to be different from other AED. Synaptic vesicle protein 2A which can block calcium release from intraneuronal stores is shown to be the binding site of levetiracetam. Thus, it works against the negative modulators of gamma-aminobutyric acid and glycin-gated currents. Moreover, LEV does not have the ablility to induce cytochrome P450 isoenzyme.[2]

A study has shown that an oral dose of LEV can’t bind to plasma proteins, while no hepatic metabolism was observed. One-third of the metabolized drug was found to be hydrolyzed and the others were excreted unchanged in the urine.[3]

References:
[1] Nabil J. Azar, Patsy Aune. Acute pancreatitis and elevated liver transaminases after rapid titration of oral levetiracetam. Journal of Clinical Neuroscience. June 2014. 21(6): 1053-1054.
[2] Xiao-Qiao Chen, Wei-Na Zhang, Zhi-Xian Yang, Meng Zhao, Fang-Cheng Cai, Shao-Ping Huang, Li Gao, Bao-Dong Pang, Xi Chen, Li-Ping Zou. Efficacy of Levetiracetam in Electrical Status Epilepticus During Sleep of Children: A Multicenter Experience. Pediatric Neurology. March 2014. 50(3): 243-249.
[3] Shahnaz Akhtar Chaudhry, Geert’t Jong, Gideon Koren. The fetal safety of Levetiracetam: A systematic review. Reproductive Toxicology. July 2014. 46: 40-45.

Chemical Properties

Cas No. 102767-28-2 SDF
别名 左乙拉西坦; UCB L059
化学名 (2S)-2-(2-oxopyrrolidin-1-yl)butanamide
Canonical SMILES CCC(C(=O)N)N1CCCC1=O
分子式 C8H14N2O2 分子量 170.21
溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 16.7 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.8751 mL 29.3755 mL 58.751 mL
5 mM 1.175 mL 5.8751 mL 11.7502 mL
10 mM 0.5875 mL 2.9375 mL 5.8751 mL
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