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L-AP4 monohydrate Sale

(Synonyms: L-APB monohydrate) 目录号 : GC61537

A selective Group III metabotropic glutamate receptor agonist

L-AP4 monohydrate Chemical Structure

Cas No.:2247534-79-6

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5 mg
¥2,340.00
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10 mg
¥4,050.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM).1,2,3 L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.1

1.Thomsen, C.The L-AP4 receptorGen. Pharmacol.29(2)151-158(1997) 2.Evans, R.H., Francis, A.A., Jones, A.W., et al.The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparationsBr. J. Pharmacol.75(1)65-75(1982) 3.Schoepp, D.D.Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous systemJ. Pharmacol. Exp. Ther.299(1)12-20(2001)

Chemical Properties

Cas No. 2247534-79-6 SDF
别名 L-APB monohydrate
Canonical SMILES O=C(O)[C@@H](N)CCP(O)(O)=O.O
分子式 C4H12NO6P 分子量 201.11
溶解度 储存条件 4°C, away from moisture and light
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.9724 mL 24.862 mL 49.724 mL
5 mM 0.9945 mL 4.9724 mL 9.9448 mL
10 mM 0.4972 mL 2.4862 mL 4.9724 mL
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