Ipronidazole
(Synonyms: 异丙硝唑) 目录号 : GC49774
A nitroimidazole antiprotozoal agent
Cas No.:14885-29-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
1-Methyl-2-isopropyl-5-nitroimidazole Ipronidazole is a nitroimidazole antiprotozoal agent.1 Dietary administration of ipronidazole (0.00312-0.0094% w/w) reduces H. meleagridis-induced mortality in young turkeys. It also induces 100% disease clearance in bulls infected with T. foetus when administered at a dose of 60 g/animal.2 Formulations containing ipronidazole have been used in the treatment of veterinary histomoniasis in turkeys and swine dysentery.
1.Bowen, T.E., Sullivan, T.W., and Grace, O.D.Effect of cupric sulfate on the prophylactic efficacy of 2-acetylamino-5nitrothiazole, nifursol and ipronidazole against histomoniasis in turkeysPoult. Sci.50(6)1668-1672(1971) 2.Skirrow, S.Z., and Bondurant, R.H.Treatment of bovine trichomoniasis with ipronidazoleAust. Vet. J.65(5)156(1988)
| Cas No. | 14885-29-1 | SDF | Download SDF |
| 别名 | 异丙硝唑 | ||
| Canonical SMILES | [O]=[N](C1=C[N]=C(C(C)C)[N]1C)=[O] | ||
| 分子式 | C7H11N3O2 | 分子量 | 169.2 |
| 溶解度 | DMF: 14 mg/mL,DMSO: 11 mg/mL,Ethanol: 12 mg/mL,PBS (pH 7.2): 0.16 mg/mL | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.9102 mL | 29.5508 mL | 59.1017 mL |
| 5 mM | 1.182 mL | 5.9102 mL | 11.8203 mL |
| 10 mM | 0.591 mL | 2.9551 mL | 5.9102 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Effects of metronidazole, Ipronidazole, and dibromochloropropane on rabbit and human sperm motility and fertility
Reprod Toxicol 2002 Nov-Dec;16(6):749-55.PMID:12401502DOI:10.1016/s0890-6238(02)00052-7.
Treatment of protozoal pathogens in the reproductive system with chemical agents exposes flagellated sperm cells to potential toxicants. A widely used antiprotozoal agent is metronidazole. Its effect on rabbit and human sperm was compared with a more soluble 5-nitroazole compound, Ipronidazole, and with a systemic environmental toxicant, dibromochloropropane (DBCP). The percentages of motile rabbit and human sperm incubated with the compounds, the velocity of sperm, migration of sperm in polyacrylamide gel, young born in rabbits, and penetration of hamster oocytes by treated human sperm were measured in seven experiments. Up to 10mg/ml metronidazole and 1mg/ml DBCP had little effect on most sperm characteristics. However, 10mg/ml metronidazole and 5mg/ml of Ipronidazole increased attachment of human sperm to hamster oocytes, but oocyte penetration was unaffected. Rabbit sperm exposed to 5mg/ml Ipronidazole were infertile. No oocytes were penetrated by DBCP-treated human sperm.
Efficacy of Ipronidazole against trichomoniasis in beef bulls
J Am Vet Med Assoc 1985 Aug 15;187(4):405-7.PMID:4030475doi
Preputial smegma samples from 195 beef bulls were collected repeatedly and cultured for Tritrichomonas foetus. Seventy-five (38.5%) of these bulls were positive for trichomonads on at least 1 culture. Sensitivity of the culture procedure (number of positive cultures/number of total cultures from known-positive bulls) was 81.6%. Storage of preputial smegma in lactated Ringer's solution at 5 C for 24 hours resulted in a 14% loss of sensitivity. Seventy-three of the 75 infected bulls were available for treatment and were alloted randomly to 2 groups. Bulls in both groups were treated with procaine penicillin (7,000 IU/kg, IM) for 2 days before Ipronidazole treatment. Thirty grams of Ipronidazole powder was dissolved in 60 ml of sterile water, and was given IM to group 1 bulls. Group 2 bulls were given a similar 30-g Ipronidazole solution IM on day 1, and were given 15 g of Ipronidazole dissolved in 30 ml of sterile water on days 2 and 3. Efficacy of treatment (ie, negative cultures of preputial smegma for trichomonads for 6 consecutive weeks after treatment) was 92.8% for the 42 bulls treated once and 100% for the 31 bulls treated 3 times.
Performance of turkey poults when fed two levels of methionine with and without Ipronidazole
Poult Sci 1987 Nov;66(11):1887-8.PMID:3447150DOI:10.3382/ps.0661887.
Two experiments were conducted to determine the effect of adding Ipronidazole to the diet of turkey poults containing two different levels of methionine. A corn-soybean meal diet with 0 to .18% supplemental methionine was fed to Nicholas Large White poults from 1 to 21 days of age. The addition of .18% supplemental methionine significantly improved body weight and feed efficiency. The addition of Ipronidazole to the diet with either level of methionine did not influence body weight, feed efficiency, or grams of sulfur amino acid required to produce a gram of weight.
Treatment of giardiasis in adult Greyhounds, using ipronidazole-medicated water
J Am Vet Med Assoc 1986 Jan 1;188(1):67-9.PMID:3944011doi
Two of 3 adult Greyhounds with clinical signs of giardiasis were treated by the addition of Ipronidazole hydrochloride to their water supply (126 mg/L) for 7 days. Within 15 hours, the dogs had improved clinically, and large numbers of degenerating Giardia cysts were passed. After 54 hours, cyst shedding had ceased. The nontreated control dog continued to shed Giardia cysts. During an additional 7 days, the dogs were treated with ipronidazole-medicated water (378 mg/L) and remained clinically normal.
The mutagenic action of nitroimidazoles. II. Tinidazole, Ipronidazole, panidazole and ornidazole
Mutat Res 1977 Apr;48(2):155-61.PMID:327306DOI:10.1016/0027-5107(77)90155-5.
The 5-nitroimidazoles tinidazole (Fasigyn), Ipronidazole (Ro-7-1554), panidazole and ornidazole (Tiberal, Ro-7-0207) in concentrations of 0.02--1 mM per liter increased the mutation frequency of Klebsiella pneumoniae. Escherichia coli K12 and Citrobacter freundii to streptomycin resistance, including streptomycin dependence, in Luria and Delbrück's fluctuation test. At low concentration (0.1 mM), the increase of the mutation frequency caused by each compound was nearly the same, i.e. 3--4 times the spontaneous mutation frequency. At higher concentrations, considerable differences between the mutagenic activities of the compounds occurred.