Infectious Disease(传染病)

Cat.No. 产品名称 Information

GC65043 Haemanthamine Haemanthamine 是从 Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。

GC65034 Ibalizumab

伊巴组单抗,TMB-355; TNX-355

Ibalizumab (TMB-355) 是一种人源化 IgG4 单克隆抗体，通过与 CD4 受体结合来阻止 HIV 细胞进入。Ibalizumab 具有用于 HIV-1 感染研究的潜力。

GC64484 Emivirine

MKC-442

Emivirine (MKC-442) 是有效的非核苷逆转录酶的抑制剂 (NNRTIs)，对dTTP 和 dGTP 依赖性 DNA 或 RNA 聚合酶活性的 Ki 值分别为 0.20 和 0.01 μM。Emivirine 具有有效且选择性的抗 HIV-1 活性。

GC64391 DDX3-IN-2 DDX3-IN-2 是一种活性 DEADbox polypeptide 3 (DDX3) 抑制剂，其 IC50 值 0.3 μM。DDX3-IN-2 表现出广谱的抗病毒活性。DDX3-IN-2 有克服 HIV 耐药的潜力。

GC52120 DMPE-MPEG(2000)

1,2-Dimyristoyl-rac-glycero-3-PE-methoxy-Polyethyleneglycol-2000, 1,2-DMPE-MPEG(2000)

A PEGylated form of DMPE

GC52119 Lansoprazole sulfone N-oxide

兰索拉唑枫氮氧化物

A potential impurity found in commercial preparations of lansoprazole

GC52101 Brazilein A phytochemical with diverse biological activities

GC52095 Dodecyltrimethylammonium (bromide)

十二烷基三甲基溴化铵

A cationic surfactant

GC52088 Methylchloroisothiazolinone (hydrochloride)

5-氯-2-甲基异噻唑啉-3-酮盐酸盐

A biocide

GC52084 YSK05 An ionizable cationic amino lipid

GC52082 Dimidium (bromide)

溴化底米鎓

A trypanocide

GC52073 N-formyl-2-Aminophenol

2’-Hydroxyformanilide, NSC 93900

A bacterial secondary metabolite with antioxidant activity

GC52072 Febrifugine (hydrochloride)

常山乙素二盐酸盐

A quinazolinone with antimalarial activity

GC52059 AMOZ

硝基呋喃代谢物AMOZ,3-Amino-5-morpholinomethyl-2-oxazolidone

A metabolite of furaltadone

GC52045 N-desmethyl Azelastine

氮卓斯汀杂质

An active metabolite of azelastine

GC52040 Ipronidazole-d3

异丙硝唑-D3

An internal standard for the quantification of ipronidazole

GC52029 2-Aminoflubendazole

2-氨基氟苯咪唑

A metabolite of flubendazole

GC52014 Forphenicinol

Forfenimex

An immunomodulator and a derivative of forphenicine

GC52007 N-hydroxylamine Dapsone

羟胺氨苯砜

An active metabolite of dapsone

GC19941 DL-Leucic Acid

GC49915 Hexa-D-Arginine (trifluoroacetate salt)

Furin Inhibitor II, Hexa-D-Arg-NH2, Hexa-D-Arginine amide, D6R-NH2, (D)RRRRRR-NH2

A furin inhibitor

GC49912 13C20,15N10-Cyclic di-GMP (sodium salt)

13C20,15N10-c-di-GMP, 13C20,15N10-Cyclic diguanylate, 13C20,15N10-3’,5’-Cyclic diguanylic Acid

An internal standard for the quantification of cyclic di-GMP

GC49898 Penicillin G-d5 (potassium salt)

Benzylpenicillin-d5

An internal standard for the quantification of penicillin G

GC49863 Cytarabine 5′-monophosphate

ara-CMP, 1-β-D-Arabinofuranosylcytosine 5'-monophosphate, Cytosine Arabinoside monophosphate, NSC 99445

An active metabolite of cytarabine

GC49852 Clindamycin (hydrochloride hydrate)

盐酸克林霉素

A lincosamide antibiotic

GC49847 3-hydroxy methyl Cefuroxime

头孢呋辛钠EP杂质A

A synthetic intermediate

GC49837 Gypsogenic Acid

Astrantiagenin J

A triterpene acid with antibacterial and trypanocidal activities

GC49832 Hydroxymetronidazole

羟基甲硝唑,Metronidazole-OH

An active metabolite of metronidazole

GC49823 2′-C-β-Methylguanosine

2'-C-甲基鸟苷

An active nucleoside metabolite of BMS-986094

GC49821 Cyclamidomycin

赛拉霉素

A bacterial metabolite with antibiotic activity

GC49819 3-Hydroxy-4-methyl-2(5H)-thiophenone

头孢氨苄杂质D

A degradation product of cefaclor

GC49808 12-methyl Tridecanoic Acid

12-甲基十三烷酸

A methylated fatty acid

GC49804 Acridine

吖啶

An azaarene

GC49793 Bacitracin A (technical grade)

杆菌肽A

A polypeptide antibiotic

GC49792 D-(+)-Cellopentaose

D-(+)-纤维五糖

An oligosaccharide

GC49790 Reuterin

罗氏菌素,3-Hydroxypropionaldehyde; 3-Hydroxypropanal

A bacterial glycerol metabolite with antibacterial activity

GC49786 2-NP-AOZ

2-NP-呋喃唑酮

A derivatized metabolite of furazolidone

GC49774 Ipronidazole

异丙硝唑

A nitroimidazole antiprotozoal agent

GC49773 Albendazole sulfone-d3

阿苯哒唑砜-D3

An internal standard for the quantification of albendazole sulfone

GC49766 Abafungin

阿巴芬净,BAY-W-6341

An antifungal agent

GC49765 PF-04753299 An inhibitor of LpxC

GC49759 13C17-Mycophenolic Acid

霉酚酸-(全碳-13)

An internal standard for the quantification of mycophenolic acid

GC49753 LCS3 An inhibitor of glutathione reductase and thioredoxin reductase

GC49751 Lefamulin

来法莫林,BC-3781

A pleuromutilin antibiotic

GC49749 6-Deoxypenciclovir

泛昔洛韦USPRCA

An inactive metabolite of famciclovir

GC64378 Valproic acid-d6

丙戊酸-D6,VPA-d6; 2-Propylpentanoic Acid-d6

Valproic acid-d6 (VPA-d6) 是 Valproic acid 的氘代物。Valproic acid (VPA; 2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，IC50 值为 0.5-2 mM，抑制 HDAC1 的活性，(IC50，400 μM)，同时可诱导 HDAC2 的降解。Valproic acid 激活 Notch1 信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍和偏头痛等的研究。

GC64348 Cyanidin 3-sambubioside chloride

氯化花青素-3-桑布双糖苷,Cyanidin-3-O-sambubioside chloride

Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride)，一种主要的花色苷，一种天然着色剂，是一种有效的 NO 抑制剂。Cyanidin 3-sambubioside chloride 是 H274Y 突变抑制剂，可抑制流感神经氨酸酶 (neuraminidase) 活性，IC50 为 72 μM。Cyanidin 3-sambubioside chloride 抑制血管紧张素转换酶 (ACE) 的活性，并具有抗氧化，抗血管生成和抗病毒特性。

GC64333 Oseltamivir-d5 phosphate

GS 4104-d5

Oseltamivir-d5 phosphate (GS 4104-d5) 是 Oseltamivir phosphate 的氘代物。Oseltamivir phosphate (GS 4104) 是一种神经氨酸酶 (neuraminidase) 抑制剂，用于流感 (influenza A 和 B) 的研究。

GC64331 Ritonavir-13C,d3

ABT 538-13C,d3; RTV-13C,d3

Ritonavir-13C,d3 (ABT 538-13C,d3) 是一种 13C- 和氘代标记的 Ritonavir。Ritonavir (ABT 538) 是用于研究 HIV 感染和 AIDS 的 HIV 蛋白酶的抑制剂。Ritonavir 也是 SARS-CoV 3CLpro 的抑制剂，IC50 为 1.61 μM。

GC64270 Decanoyl-RVKR-CMK TFA

DecRVKRcmk TFA

Decanoyl-RVKR-CMK (DecRVKRcmk) TFA 抑制过表达的 gp160 加工和 HIV-1 的复制。