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HSP70-IN-1 Sale

目录号 : GC32869

HSP70-IN-1是一种热休克蛋白(HSP)抑制剂;抑制Kasumi-1细胞的生长的IC50值为2.3μM。

HSP70-IN-1 Chemical Structure

Cas No.:1268273-90-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥3,010.00
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1mg
¥982.00
现货
5mg
¥2,945.00
现货
10mg
¥4,463.00
现货
50mg
¥13,388.00
现货
100mg
¥18,743.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.

The heat shock protein 70 (Hsp70) is a molecular chaperone which plays an important function in protein homeostasis as well as in cell signaling and survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is furthermore believed to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life[1].

[1]. Taldone T, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014 Feb 27;57(4):1208-24.

Chemical Properties

Cas No. 1268273-90-0 SDF
Canonical SMILES O=C(NC1=CC=CC(SC2=CN=C(N3CCN(C)CC3)N=C2OCC4=CC=CC=C4)=C1)CN
分子式 C24H28N6O2S 分子量 464.58
溶解度 DMSO : 50 mg/mL (107.62 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1525 mL 10.7624 mL 21.5248 mL
5 mM 0.4305 mL 2.1525 mL 4.305 mL
10 mM 0.2152 mL 1.0762 mL 2.1525 mL
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