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Homosalate (Homomenthyl salicylate) Sale

(Synonyms: 胡莫柳酯; Homomenthyl salicylate) 目录号 : GC30249

Homosalate (HMS, Homomenthyl salicylate) is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.

Homosalate (Homomenthyl salicylate) Chemical Structure

Cas No.:118-56-9

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100mg
¥446.00
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产品描述

Homosalate (HMS, Homomenthyl salicylate) is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.

Extracellular vesicles (EVs) released by Homosalate‐treated cells enhance resistance to anchorage loss in another recipient epithelial tumour cell line.[2]

[1] Changwon Yang, et al. Environ Pollut. 2018 Dec;243(Pt B):1263-1273. [2] Grisard E, et al. J Extracell Vesicles. 2022 Jul;11(7):e12242.

Chemical Properties

Cas No. 118-56-9 SDF
别名 胡莫柳酯; Homomenthyl salicylate
Canonical SMILES O=C(OC1CC(C)(C)CC(C)C1)C2=CC=CC=C2O
分子式 C16H22O3 分子量 262.34
溶解度 DMSO : ≥ 55 mg/mL (209.65 mM) 储存条件 Store at -20°C
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1 mM 3.8118 mL 19.0592 mL 38.1185 mL
5 mM 0.7624 mL 3.8118 mL 7.6237 mL
10 mM 0.3812 mL 1.9059 mL 3.8118 mL
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Research Update

Diastereoselective metabolism of homomenthyl salicylate (homosalate): Identification of relevant human exposure biomarkers

Homosalate (HMS) is a salicylate UV filter broadly used in sunscreens and personal care products. The aim of this study was the collection of human toxicokinetic data on HMS as a tool for risk assessment. For this purpose, metabolism and urinary excretion after a single oral HMS dose (98.2-149.1 ?g (kg body weight)-1) were investigated in four volunteers (two male, two female). As commercial products generally contain a mixture of cis- and trans-HMS, both cis-rich and trans-rich isomer mixtures were studied to investigate possible differences in metabolism. Initial metabolite screening tentatively identified six oxidative metabolite subgroups, of which hydroxylated and carboxylic acid metabolites were studied in more detail. Unchanged parent HMS and the previously identified HMS metabolites 5-((2-hydroxybenzoyl)oxy)-3,3-dimethylcyclohexane-1-carboxylic acid (HMS-CA) and 3-hydroxy-3,5,5-trimethylcyclohexyl 2-hydroxybenzoate (3OH-HMS), respectively, were quantified separately as cis- and trans-isomers via authentic standards by isotope dilution analysis. In addition, further alkyl-hydroxylated and carboxylic acid metabolites were investigated semi-quantitatively. Peak concentrations in urine were reached 1.5-6.3 h post-dose and more than 80 % of each of the quantitatively investigated metabolites (and at least 70 % of the semi-quantitatively investigated metabolites) was excreted within the first 24 h. Plasma and urine data indicated that oral bioavailability of cis-HMS was one order of magnitude below that of trans-HMS. Furthermore, the mean total urinary excretion fraction (Fue) for the metabolites derived from trans-HMS (6.4 %) was two orders of magnitude higher than for the metabolites derived from cis-HMS (0.045 %). Our data proves diastereoselectivity in toxicokinetics of cis- and trans-HMS, emphasizing the necessity to address isomer ratios in future studies including HMS exposure and risk assessments.

A novel characteristic of salicylate UV absorbers: suppression of diethylhexyl 2,6-naphthalate (Corapan TQ)-photosensitized singlet oxygen generation

2-Ethylhexyl salicylate (EHS, octyl salicylate) and homomenthyl salicylate (HMS, homosalate) are UV-B absorbers used in cosmetic sunscreens. Diethylhexyl 2,6-naphthalate (DEHN, tradename Corapan TQ) used as a mildly effective photostabilizer for labile butylmethoxydibenzoylmethane, the most widely used UV-A absorber, is an efficient singlet oxygen photosensitizer with a high quantum yield of singlet oxygen generation ΦΔ = 0.44 in ethanol. The effects of EHS, HMS, l-ascorbic acid (AA, vitamin C), 3-O-ethyl-l-ascorbic acid (3-EtAA) and Trolox (TX, a water-soluble analogue of vitamin E) on DEHN-photosensitized singlet oxygen generation have been studied through measurements of time-resolved near-infrared phosphorescence in ethanol. These compounds suppress DEHN-photosensitized singlet oxygen generation. 40% of ΦΔ is decreased by adding 32 mmol dm-3 EHS or HMS. ΦΔ is decreased to a half by adding 3.0 mmol dm-3 TX. Fluorescence and transient absorption measurements suggest that the observed suppression is due to the quenching of the excited singlet state of DEHN by EHS, HMS, AA and 3-EtAA. These compounds do not quench the excited triplet state of DEHN. On the other hand, TX quenches both the excited singlet and triplet states of DEHN. It was shown that these UV-B absorbers have a novel characteristic as a suppressor of photosensitized singlet oxygen generation. Suppressing singlet oxygen generation is an important method for the prevention of skin damage. To the best of our knowledge, this is the first report on the suppression of photosensitized singlet oxygen generation by UV absorbing molecules.