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HNHA Sale

(Synonyms: N-羟基-7-(2-萘硫基)-庚酰胺,Histone Deacetylase Inhibitor VI) 目录号 : GC12334

HDAC inhibitor

HNHA Chemical Structure

Cas No.:926908-04-5

规格 价格 库存 购买数量
5mg
¥1,190.00
现货
10mg
¥2,221.00
现货
25mg
¥5,266.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

IC50: 100 nM

HNHA is an HDAC inhibitor.

Histone acetylation is regulated by two covalent modifying enzymes, acetylases and deacetylases, and plays a key role in gene expression of eukaryotes. It has been revealed that histone deacetylase (HDAC), which is overexpressed in several tumor cells. plays a critical role in carcinogenesis. Moreover, plenty of studies have showed that the expression of tumor suppressors including p53, p21, and gelsolin, are repressed, whereas, tumor activators including hypoxia-induced factor-1 and vascular endothelial growth factor, are up-regulated in HDAC-overexpressed cells.

In vitro: Previous study found that HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080). In addition, treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion [1].

In vivo: The effects of HNHA on human cancer cells bearing xenograph mice was examined. Results showed that as expected, HNHA could dramatically reduce tumor volume as to (vehicle) control. In addition, HNHA had a stronger potency than that of SAHA, which implied that the pharmacological potency of HNHA was better than SAHA in vivo [1].

Clinical trial: So far, no clinical study has been conducted.

Reference:
1.  Kim, D.H.,Lee, J.,Kim, K.N., et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. Biochemical and Biophysical Research Communications 356, 233-238 (2007).

Chemical Properties

Cas No. 926908-04-5 SDF
别名 N-羟基-7-(2-萘硫基)-庚酰胺,Histone Deacetylase Inhibitor VI
化学名 N-hydroxy-7-(2-naphthalenylthio)-heptanamide
Canonical SMILES c1ccc2c(c1)cc(cc2)SCCCCCCC(NO)=O
分子式 C17H21NO2S 分子量 303.4
溶解度 ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.296 mL 16.4799 mL 32.9598 mL
5 mM 0.6592 mL 3.296 mL 6.592 mL
10 mM 0.3296 mL 1.648 mL 3.296 mL
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