Heptacosanoic Acid
(Synonyms: 二十七烷酸) 目录号 : GC49660
An odd-chain saturated fatty acid
Cas No.:7138-40-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Heptacosanoic acid is an odd-chain saturated fatty acid. It has been used as an internal standard for the quantification of very long-chain fatty acids (VLCFAs) in human serum.1 Heptacosanoic acid has been found in wood smoke, as well as in urban and rural emissions of fine particulate matter less than 2.5 µm in aerodynamic diameter (PM2.5).2,3
1.Paik, M.J., Lee, K.O., and Shin, H.S.Determination of very-long-chain fatty acids in serum by gas chromatography-nitrogen-phosphorus detection following cyanomethylationJ. Chromatogr. B Biomed. Sci. Appl.721(1)3-11(1999) 2.Rogge, W.F., Hildemann, L.M., Mazurek, M.A., et al.Sources of fine organic aerosol. 9. Pine, oak, and synthetic log combustion in residential fireplacesEnviron. Sci. Technol.32(1)13-22(1998) 3.Zheng, M., Cass, G.R., Schauer, J.J., et al.Source apportionment of PM2.5 in the southeastern United States using solvent-extractable organic compounds as tracersEnviron. Sci. Technol.36(11)2361-2371(2002)
| Cas No. | 7138-40-1 | SDF | Download SDF |
| 别名 | 二十七烷酸 | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O | ||
| 分子式 | C27H54O2 | 分子量 | 410.7 |
| 溶解度 | Chloroform: Slightly soluble,DMF: Slightly soluble,DMSO: Slightly soluble,Hexane: Slightly soluble,PBS (pH 7.2): Slightly soluble,Water: Slightly soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4349 mL | 12.1743 mL | 24.3487 mL |
| 5 mM | 0.487 mL | 2.4349 mL | 4.8697 mL |
| 10 mM | 0.2435 mL | 1.2174 mL | 2.4349 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Determination of very-long-chain fatty acids in serum by gas chromatography-nitrogen-phosphorus detection following cyanomethylation
J Chromatogr B Biomed Sci Appl 1999 Jan 8;721(1):3-11.PMID:10027631DOI:10.1016/s0378-4347(98)00436-8.
A sensitive method for very-long-chain fatty acid analysis was developed by gas chromatography-nitrogen-phosphorus detection by using cyanomethyl derivatization. Bromoacetonitrile as alkylating reagent was used to improve nitrogen phosphorus detection detectability of compounds containing non-nitrogen. The carboxyl group of very-long-chain fatty acid was alkylated to cyanomethyl esters. Reaction conditions were 40 min at 60 degrees C under potassium carbonate base. Heptacosanoic Acid was used as an internal standard and hexane was used as a solvent of extraction. The extraction yield was 82.8% or more, relative standard deviation of the precision test was 8.3% or more and the result of linearity test showed a good correlation coefficient of r2=0.999 in the range of 0.1-50 microg/ml. The quantification limits were 10 ng/ml when 0.5 ml of serum was used. The present method proved simple, rapid, inexpensive and resistant to contaminants. When it was applied to serum samples taken from patients with X-linked adrenoleukodystrophy which is a hereditary X-linked disorder characterized by progressive demyelination and adrenal insufficiency during childhood, relative increase of the concentration of hexacosanoic acid and the concentration ratios of hexacosanoic, lignoceric to behenic acid was observed in comparison with control samples.
Boosting accumulation of neutral lipids in Rhodosporidium kratochvilovae HIMPA1 grown on hemp (Cannabis sativa Linn) seed aqueous extract as feedstock for biodiesel production
Bioresour Technol 2014 Aug;165:214-22.PMID:24746767DOI:10.1016/j.biortech.2014.03.142.
Hemp seeds aqueous extract (HSAE) was used as cheap renewable feedstocks to grow novel oleaginous yeast Rhodosporidium kratochvilovae HIMPA1 isolated from Himalayan permafrost soil. The yeast showed boosted triglyceride (TAG) accumulation in the lipid droplets (LDs) which were transesterified to biodiesel. The sonicated HSAE prepared lacked toxic inhibitors and showed enhanced total lipid content and lipid yield 55.56%, 8.39±0.57g/l in comparison to 41.92%, 6.2±0.8g/l from industrially used glucose synthetic medium, respectively. Supersized LDs (5.95±1.02μm) accumulated maximum TAG in sonicated HSAE grown cells were visualized by fluorescent BODIPY (505/515nm) stain. GC-MS analysis revealed unique longer carbon chain FAME profile containing Arachidic acid (C20:0) 5%, Behenic acid (C22:0) 9.7%, Heptacosanoic Acid (C27:0) 14.98%, for the first time in this yeast when grown on industrially competent sonicated HSAE, showing more similarity to algal oils.
GC-MS analysis of bioactive components and synthesis of gold nanoparticle using Chloroxylon swietenia DC leaf extract and its larvicidal activity
J Photochem Photobiol B 2015 Jul;148:1-8.PMID:25854160DOI:10.1016/j.jphotobiol.2015.03.016.
A rapid bio-reduction of chloroauric acid (HAuCl4) was achieved by Chloroxylon swietenia DC leaf extract (CSLE), which resulted in the formation of well dispersed C. swietenia gold nanoparticles (CSGNPs). The formation of GNPs was confirmed by color changes from yellowish green to purple and their characteristic peak at 545 nm. The characterization of synthesized CSGNPs was made through X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR), high resolution transmission electron microscopy (HRTEM) equipped with energy dispersive X-ray spectroscopy (EDX) followed by size and zeta potential analyses. The GC-MS profile of C. swietenia methanolic leaf extract (CSMLE) resulted 20 phytocomponents, among those Heptacosanoic Acid, 25-methyl-, methyl ester (C29H58O2) attributes highest peak area. The efficiency of the synthesized CSMLE, CSGNPs and CSLE were tested against fourth instar larvae of malarial and dengue vector, which resulted more substantial upshot than with leaf extract treated. The Lethal concentration (LC50) values of CSMLE, CSGNPs and CSLE were found to be 0.509, 0.340, 0.423 ppm and 0.602, 0.188, 0.646 ppm on Aedes aegypti and Anopheles stephensi, respectively. The findings form an important baseline information proceeding biologically innocuous biopesticide for controlling the malarial and dengue vectors.