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GZMH Human

目录号 : GP21767

Granzyme-H Human Recombinant

GZMH Human Chemical Structure

规格 价格 库存 购买数量
2μg
¥840.00
5-10工作日
10μg
¥2,030.00
5-10工作日
100μg
¥16,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

GZMH Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 248 amino acids (20-246 a.a) and having a molecular mass of 27.5kDa.GZMH is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Data

Purity Greater than 85.0% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile Filtered clear solution. Shipping Condition Shipped with Ice Packs.
Synonyms Granzyme H (Cathepsin G-Like 2; Protein H-CCPX); CTSGL2; Cytotoxic T-Lymphocyte Proteinase; CCP-X; CSP-C; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Cytotoxin Serine Protease-C; Cytotoxic Serine Protease C; Cathepsin G-Like 2; EC 3.4.21.79; EC 3.4.21; Granzyme H; EC 3.4.21; CGL-2; CTLA1; CGL2; GZMH.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRL
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Formulation GZMH protein solution (0.25mg/ml) containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.

Introduction

Granzyme H also known as GZMH belongs to the peptidase S1 family. GZMHis an essential part for HBV eradication. The HBx protein, which is requiredfor the replication of HBV, is cleaved at Met(79) by GZMH. Furthermore, GZMHinhibitor can abolish GZNH- as well as lymphokine-activated killercell-mediated HBx degradation and HBV clearance. A HBx-deficient HBV isresistant to GzmH- in addition to lymphokine-activated killer cell-mediatedviral clearance.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.