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GSK3368715 (EPZ019997) 3HCl

目录号 : GC25483

GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.

GSK3368715 (EPZ019997) 3HCl Chemical Structure

Cas No.:2227587-26-8

规格 价格 库存 购买数量
5mg
¥1,714.00
现货
25mg
¥5,143.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.

GSK3368715 is a potent, reversible, SAM uncompetitive inhibitor of type I PRMTs that produces a shift in arginine methylation states on hundreds of substrates from ADMA to MMA and SDMA. As a monotherapy, GSK3368715 induces anti-proliferative effects on cell lines from a broad range of hematological and solid tumor types in vitro.[1]

GSK3368715 has potent, anti-proliferative activity across cell lines representing a range of solid and hematological malignancies and can completely inhibit tumor growth or cause regressions of tumor models in vivo.[1]

[1] Andrew Fedoriw, et al. Cancer Cell. 2019 Jul 8;36(1):100-114.e25.

Chemical Properties

Cas No. 2227587-26-8 SDF Download SDF
分子式 C20H41Cl3N4O2 分子量 475.92
溶解度 DMSO: 81 mg/mL (170.20 mM);Water: 81 mg/mL (170.20 mM);Ethanol: 81 mg/mL (170.20 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.1012 mL 10.506 mL 21.0119 mL
5 mM 0.4202 mL 2.1012 mL 4.2024 mL
10 mM 0.2101 mL 1.0506 mL 2.1012 mL
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