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GSK-LSD1 Dihydrochloride Sale

目录号 : GC32764

An LSD1 inhibitor

GSK-LSD1 Dihydrochloride Chemical Structure

Cas No.:2102933-95-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥785.00
现货
5mg
¥714.00
现货
10mg
¥1,071.00
现货
25mg
¥2,142.00
现货
50mg
¥3,749.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO).1 LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression.2 It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370).3 GSK-LSD1 is an irreversible, mechanism-based inhibitor of LSD1 (IC50 = 16 nM) that is >1,000-fold selective over the closely related FAD-utilizing enzymes LSD2, MAO-A, and MAO-B.4 GSK-LSD1 induces gene expression changes in various cancer cell lines, inhibiting their proliferation (EC50s <5 nM).4 See the Structural Genomics Consortium (SGC) website for more information.

1.Shi, Y., Lan, F., Matson, C., et al.Histone demethylation mediated by the nuclear amine oxidase homolog LSD1Cell119(7)941-953(2004) 2.Forneris, F., Binda, C., Vanoni, M.A., et al.Human histone demethylase LSD1 reads the histone codeJ. Biol. Chem.280(50)41360-41365(2005) 3.Huang, J., Sengupta, R., Espejo, A.B., et al.p53 is regulated by the lysine demethylase LSD1Nature449105-108(2007) 4.Epigenetics probes collection(2014)

Chemical Properties

Cas No. 2102933-95-7 SDF
Canonical SMILES C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1.Cl.Cl
分子式 C14H22Cl2N2 分子量 289.24
溶解度 DMSO : ≥ 62.5 mg/mL (216.08 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.4573 mL 17.2867 mL 34.5734 mL
5 mM 0.6915 mL 3.4573 mL 6.9147 mL
10 mM 0.3457 mL 1.7287 mL 3.4573 mL
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