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Glucosylceramide (bovine buttermilk)

(Synonyms: GluCers (buttermilk), Glucocerebrosides (buttermilk)) 目录号 : GC52493

A sphingolipid

Glucosylceramide (bovine buttermilk) Chemical Structure

规格 价格 库存 购买数量
500 μg
¥854.00
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1 mg
¥1,596.00
现货
5 mg
¥3,332.00
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50 mg
¥24,948.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Glucosylceramides are formed by the tethering of glucose to a ceramide by glucosylceramides synthase.1 They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species, where they comprise 5-30% of total lipids in the plant plasma membrane, and in fungi.1,2,3 Glucosylceramides levels decrease during cold acclimatization in plants and glucosylceramides in fungi are involved in the regulation of virulence and act as elicitors in plants, stimulating plant defense mechanisms.3,4 Glucosylceramides are precursors in the synthesis of lactosylceramides and gangliosides. Increased levels of glucosylceramides are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease.1,5 This product contains glucosylceramide molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1521]

1.Holland, W.L., and Summers, S.A.Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolismEndocr. Rev.29(4)381-402(2008) 2.Cahoon, E.B., and Lynch, D.V.Analysis of glucocerebrosides of rye (Secale cereale L. cv Puma) leaf and plasma membranePlant Physiol.95(1)56-68(1991) 3.Lynch, D.V., and Dunn, T.M.An introduction to plant sphingolipids and a review of recent advances in understanding their metabolism and functionNew Phytol.161(3)667-702(2004) 4.Rollin-Pinheiro, R., Bernardino, M.C., and Barreto-Bergter, E.Sphingolipids: Functional and biological aspects in mammals, plants, and fungiAnalysis of membrane lipids21-40(2020) 5.Dai, M., Liou, B., Swope, B., et al.Progression of behavioral and CNS deficits in a viable murine model of chronic neuronopathic Gaucher diseasePLoS One11(9)e0162367(2016)

Chemical Properties

Cas No. SDF Download SDF
别名 GluCers (buttermilk), Glucocerebrosides (buttermilk)
Canonical SMILES O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)[C@@H]1O
分子式 C46H89NO8 (for docosanoyl) 分子量 784.2
溶解度 Chloroform:Methanol (2:1): Soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2752 mL 6.3759 mL 12.7518 mL
5 mM 0.255 mL 1.2752 mL 2.5504 mL
10 mM 0.1275 mL 0.6376 mL 1.2752 mL
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