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Globotriaosylceramide (non-hydroxy) (porcine RBC)

(Synonyms: Ceramide Trihexosides (top spot) (porcine)) 目录号 : GC52491

A sphingolipid

Globotriaosylceramide (non-hydroxy) (porcine RBC) Chemical Structure

规格 价格 库存 购买数量
500 μg
¥5,334.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides .1 They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo.2 Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A.3 Globotriaosylceramides act as natural resistance factors to HIV infection, interacting with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes.1This product contains non-hydroxy fatty acid-containing globotriaosylceramide molecular species with primarily C22:0 and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1513]

1.Lingwood, C.A., and Branch, D.R.The role of glycosphingolipids in HIV/AIDSDiscov. Med.11(59)303-313(2011) 2.Takeda, Y., Kurazono, H., and Yamasaki, S.Vero toxins (Shiga-like toxins) produced by enterohemorrhagic Escherichia coli (verocytotoxin-producing E. coli)Microbiol. Immunol.37(8)591-599(1993) 3.Feldt-Rasmussen, U., Rasmussen, A.K., Mersebach, H., et al.Fabry disease: A new challenge in endocrinology and metabolism•Eur. J. Endocrinol.146(6)741-742(2002)

Chemical Properties

Cas No. SDF Download SDF
别名 Ceramide Trihexosides (top spot) (porcine)
Canonical SMILES O[C@H]1[C@H](O[C@]2([H])O[C@H](CO)[C@H](O[C@]3([H])[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@H](O)[C@H]2O)[C@@H](CO)O[C@@H](OC[C@H](NC([R])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O
分子式 C54H101NO18 (for stearoyl) 分子量 1052.4
溶解度 Chloroform:Methanol (2:1): soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.9502 mL 4.751 mL 9.5021 mL
5 mM 0.19 mL 0.9502 mL 1.9004 mL
10 mM 0.095 mL 0.4751 mL 0.9502 mL
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
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% DMSO % % Tween 80 % saline
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