Home>>Signaling Pathways>> Microbiology & Virology>> HIV>>Globotriaosylceramide (hydroxy) (porcine RBC)

Globotriaosylceramide (hydroxy) (porcine RBC)

(Synonyms: Ceramide Trihexosides (bottom spot) (porcine)) 目录号 : GC52492

A sphingolipid

Globotriaosylceramide (hydroxy) (porcine RBC) Chemical Structure

规格 价格 库存 购买数量
500 μg
¥5,838.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides .1 They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo.2 Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A.3 Globotriaosylceramides act as natural resistance factors to HIV infection, interacting with HIV gp120 to prevent its interaction with chemokine co-receptors and subsequent fusion of HIV to host cell membranes.1 This product contains hydroxy fatty acid-containing globotriaosylceramide molecular species with primarily 2-hydroxy C24:0 and 2-hydroxy C24:1 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1514]

1.Lingwood, C.A., and Branch, D.R.The role of glycosphingolipids in HIV/AIDSDiscov. Med.11(59)303-313(2011) 2.Takeda, Y., Kurazono, H., and Yamasaki, S.Vero toxins (Shiga-like toxins) produced by enterohemorrhagic Escherichia coli (verocytotoxin-producing E. coli)Microbiol. Immunol.37(8)591-599(1993) 3.Feldt-Rasmussen, U., Rasmussen, A.K., Mersebach, H., et al.Fabry disease: A new challenge in endocrinology and metabolism•Eur. J. Endocrinol.146(6)741-742(2002)

Chemical Properties

Cas No. SDF Download SDF
别名 Ceramide Trihexosides (bottom spot) (porcine)
Canonical SMILES O[C@H]1[C@H](O[C@]2([H])O[C@H](CO)[C@H](O[C@]3([H])[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)[C@H](O)[C@H]2O)[C@@H](CO)O[C@@H](OC[C@H](NC(C(O)[R])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@@H]1O
分子式 C60H113NO19 (for hydroxytetracosanoyl) 分子量 1152.6
溶解度 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 0.8676 mL 4.338 mL 8.676 mL
5 mM 0.1735 mL 0.8676 mL 1.7352 mL
10 mM 0.0868 mL 0.4338 mL 0.8676 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置