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AF40431 Sale

目录号 : GC38586

AF40431 是首个报道的 sortilin 小分子配体,IC50 为 4.4 µM,Kd 为 0.7 µM。AF40431 结合在 sortilin 的神经降压素结合位点。

AF40431 Chemical Structure

Cas No.:181125-92-8

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1mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].

[1]. Andersen JL, et al. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60.

Chemical Properties

Cas No. 181125-92-8 SDF
Canonical SMILES CC(C)C[C@@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O
分子式 C17H21NO5 分子量 319.35
溶解度 DMSO: 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA) 储存条件 Store at -20°C
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1 mM 3.1314 mL 15.6568 mL 31.3136 mL
5 mM 0.6263 mL 3.1314 mL 6.2627 mL
10 mM 0.3131 mL 1.5657 mL 3.1314 mL
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Research Update

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex

Acta Crystallogr D Biol Crystallogr 2014 Feb;70(Pt 2):451-60.PMID:24531479DOI:10.1107/S1399004713030149.

Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors and is most abundantly expressed in the central nervous system. Sortilin has emerged as a key player in the regulation of neuronal viability and has been implicated as a possible therapeutic target in a range of disorders. Here, the identification of AF40431, the first reported small-molecule ligand of sortilin, is reported. Crystals of the sortilin-AF40431 complex were obtained by co-crystallization and the structure of the complex was solved to 2.7 Å resolution. AF40431 is bound in the neurotensin-binding site of sortilin, with the leucine moiety of AF40431 mimicking the binding mode of the C-terminal leucine of neurotensin and the 4-methylumbelliferone moiety of AF40431 forming π-stacking with a phenylalanine.