SPP
目录号 : GC38333
SPP 是一种可降解的含二硫键的 linker，可用于形成细胞毒性化合物-linker 偶联物。
Cas No.:341498-08-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate[1].
[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.
| Cas No. | 341498-08-6 | SDF | |
| Canonical SMILES | CC(SSC1=NC=CC=C1)CCC(ON2C(CCC2=O)=O)=O | ||
| 分子式 | C14H16N2O4S2 | 分子量 | 340.42 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9375 mL | 14.6877 mL | 29.3755 mL |
| 5 mM | 0.5875 mL | 2.9375 mL | 5.8751 mL |
| 10 mM | 0.2938 mL | 1.4688 mL | 2.9375 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The influence of diet on gastrointestinal Candida SPP. colonization and the susceptibility of Candida SPP. to antifungal drugs
Rocz Panstw Zakl Hig 2019;70(2):195-200.PMID:31215785DOI:10.32394/rpzh.2019.0070.
Background: Candida SPP. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract. Objective: The aim of the study was to investigate the relationship between diet and health of the study participants and the presence of gastrointestinal Candida SPP. Susceptibility of Candida to antifungal drugs was determined. Material and methods: Material comprised of oral swabs and fecal samples self-collected by the study participants. The participants filled in a nutritional questionnaire. A total of 30 people took part in the study, including 28 women and 2 men. The study was conducted in Wroclaw, Poland. Susceptibility of Candida to antifungal drugs was determined using Bio-Rad’s FUNGITEST™ Kit designed for the susceptibility testing of yeasts to six antifungal drugs. Results: In the group with negative Candida SPP. cultures, healthier wheat flour substitutes were consumed significantly more frequently than in the group with positive Candida SPP. cultures. Yellow cheeses and quark were eaten significantly more frequently in the group with negative Candida SPP. cultures. No antifungal resistance was detected in the study group. Conclusions: The increased consumption of purified wheat flour products was linked to the presence of gastrointestinal Candida SPP. A higher consumption of cheese was observed in the group with negative Candida SPP. cultures, which may indicate the inhibitory effect of saturated fatty acids on the growth of human Candida SPP. Sensitivity of C. albicans to antifungal drugs may increase effectiveness of candidiasis treatment.
SPP standing waves within plasmonic nanocavities
Opt Express 2022 Nov 21;30(24):44055-44070.PMID:36523089DOI:10.1364/OE.475586.
Surface plasmons usually take two forms: surface plasmon polaritons (SPP) and localized surface plasmons (LSP). Recent experiments demonstrate an interesting plasmon mode within plasmonic gaps, showing distinct characters from the two usual forms. In this investigation, by introducing a fundamental concept of SPP standing wave and an analytical model, we reveal the nature of the recently reported plasmon modes. The analytical model includes SPP propagating and SPP reflection within a metal-insulator-metal (MIM) cavity, which is rechecked and supplemented by numerical simulations. We systematically analyze SPP standing waves within various nanocavities. During the discussion, some unusual phenomena have been explained. For example, the hot spot of a nanodimer could be off-tip, depending on the order of standing wave mode; and that a nanocube on metal film can be viewed as a nanocube dimer with the same separation. And many other interesting phenomena have been discussed, such as dark mode of SPP standing wave and extraordinary optical transmission. The study gives a comprehensive understanding of SPP standing waves, and may promote the applications of cavity plasmons in ultrasensitive bio-sensings.
HACEK endocarditis: state-of-the-art
Expert Rev Anti Infect Ther 2016;14(5):523-30.PMID:26953488DOI:10.1586/14787210.2016.1164032.
The HACEK group of bacteria - Haemophilus parainfluenzae, Aggregatibacter SPP. (A. actinomycetemcomitans, A. aphrophilus, A. paraphrophilus, and A. segnis), Cardiobacterium SPP. (C. hominis, C. valvarum), Eikenella corrodens, and Kingella SPP. (K. kingae, K. denitrificans) - are fastidious gram-negative bacteria, part of the normal microbiota of oral and upper respiratory tract in humans. Although their pathogenicity is limited, they are responsible for 1-3% of all infective endocarditis. HACEK endocarditis mostly affect patients with underlying heart disease or prosthetic valves, and are characterized by an insidious course, with a mean diagnosis delay of 1 month (Haemophilus SPP.) to 3 months (Aggregatibacter and Cardiobacterium SPP.). The advent of continuously monitored blood culture systems with enriched media has erased the need for extended incubation for the diagnosis of HACEK endocarditis. Medical treatment relies on third-generation cephalosporin, with a favorable outcome in 80-90% of cases, with or without cardiac surgery.
The role of habitat in the facilitation of Ostreopsis SPP. blooms
Harmful Algae 2022 Mar;113:102199.PMID:35287932DOI:10.1016/j.hal.2022.102199.
In recent decades, recurrent Ostreopsis SPP. blooms have been recorded throughout the globe, causing public health issues and mass mortalities of invertebrates. Ostreopsis species are benthic and develop in shallow waters in close relation with a substrate, but possible substrate preferences are still ambiguous. Bloom develops on both living and dead substrates and several interacting biotic and abiotic factors acting at different spatial scales can potentially foster or regulate Ostreopsis SPP. development. The objective of this review is to collect and summarize information on Ostreopsis SPP. blooms related to the habitat at different spatial scales, in order to assess preferences and trends. References including Ostreopsis SPP. samplings in the field were analysed in this review, as potentially including information about the micro- (substrate), meso‑ (community) and macrohabitat (ecosystem) related to Ostreopsis SPP. blooms. The sampled substrate and the ecosystem where Ostreopsis SPP. were collected were generally reported and described in the studies, while the description of the mesohabitat was rarely reported. Ostreopsis SPP. were generally described as attached to biotic substrates and in particular, macroalgae, even in studies conducted in coral reefs, where macroalgae are generally not dominant (but they can be in case of coral reef degradation). In both temperate and tropical areas, Ostreopsis SPP. were mostly sampled on algal species usually forming medium or low complexity communities (erect or turf-forming algae), often characteristic from post-regime shift scenarios, and rarely on canopy-forming species (such as fucoids and kelps). This literature review highlights the need of collecting more information about the mesohabitat where important Ostreopsis SPP. blooms develop, as much as of the underlying mechanisms driving eventual differences on Ostreopsis SPP. abundances. This knowledge would allow a better risk assessment of Ostreopsis SPP. blooms, identifying areas at high risk on the base of the benthic habitats.
SPP waveguide based on the Goos-Hänchen effect
Opt Lett 2021 Aug 15;46(16):4029-4032.PMID:34388803DOI:10.1364/OL.434373.
We propose and realize a single-mode surface plasmon polariton (SPP) waveguide formed by two parallel grooves on the surface of a high-quality silver film. In the waveguide, the SPP wave undergoes the Goos-Hänchen shift of up to 0.77⋅λSPP at each successive reflection, with the electric field of the SPP wave outside the metal, which significantly reduces the metal loss of the guided SPP wave. Using the waveguide, we demonstrate a complex on-chip optical circuit that includes (1) SPP plane wave excitation, (2) SPP plane wave focusing with a parabolic mirror, and (3) coupling of the focused SPP wave to the waveguide.