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SN 2 Sale

目录号 : GC37655

SN 2 是一种有效的 TRPML3 离子通道激活剂,EC50 为 1.8±0.13 μM。

SN 2 Chemical Structure

Cas No.:823218-99-1

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10mM (in 1mL DMSO)
¥1,109.00
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10mg
¥1,008.00
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50mg
¥4,212.00
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100mg 待询 待询
200mg 待询 待询

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Sample solution is provided at 25 µL, 10mM.

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产品描述

SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM. EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]

The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at -80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at -80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].

[1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.

Chemical Properties

Cas No. 823218-99-1 SDF
Canonical SMILES CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4
分子式 C17H21NO 分子量 255.35
溶解度 DMSO: 100 mg/mL (391.62 mM) 储存条件 Store at -20°C
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1 mM 3.9162 mL 19.581 mL 39.1619 mL
5 mM 0.7832 mL 3.9162 mL 7.8324 mL
10 mM 0.3916 mL 1.9581 mL 3.9162 mL
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Research Update

Total and SN-2 Fatty Acid Profile in Human Colostrum and Mature Breast Milk of Women Living in Inland and Coastal Areas of China

Ann Nutr Metab 2021;77(1):29-37.PMID:33730729DOI:10.1159/000510379.

Introduction: Although lipid is the major energy source and exerts beneficial effects on infant growth, research on the composition of fatty acid (FA) at the SN-2 position of human milk (HM) in China and abroad is limited. Objectives: This study aimed to investigate the FA positional distribution in colostrum and mature HM of women living in the inland and coastal areas of China and explore the potential influences of geographical region and lactation stage on the FA profile of Chinese women. Methods: Colostrum milk (n = 61) and mature milk (n = 56) samples were obtained longitudinally from healthy lactating women in Guangzhou and Chengdu, China. Gas chromatography was used to determine the total and SN-2 FA composition. Results: Significant differences were observed in the FA profile of HM between different regions and lactation stages, with differences in polyunsaturated FA levels being the most pronounced. Nearly 70% of SN-2 FAs were saturated FAs, of which C16:0 accounted for approximately 75%. C8:0, C10:0, C18:0, C20:0, C22:0, and all of the unsaturated FAs were mainly located at the sn-1 and sn-3 positions, while C14:0, C15:0, and C16:0 were mainly at the SN-2 position. The proportion of C12:0 and C17:0 at SN-2 was approximately equivalent to that at the sn-1, 3 positions. Conclusions: The results indicate the variability in the FA profile of HM between regions and lactation stages. The contents of polyunsaturated FAs and SN-2 FAs, especially palmitic acid, should be paid more attention when optimizing infant formula.