Fucosylated Ganglioside GM1 (porcine) (ammonium salt)
(Synonyms: Fucosylated Monosialoganglioside GM1, Fucosyl GM1) 目录号 : GC52483A sphingolipid
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fucosylated ganglioside GM1 is a fucose-containing glycosphingolipid that was originally found in bovine thyroid tissue.1 It has been found in isolated human small cell lung cancer (SCLC) tumors but is rarely found in other types of lung cancer tumors or normal tissue.2 Fucosylated ganglioside GM1 is shed from SCLC cells in vitro and in vivo in SCLC nude mouse xenograft models and can be detected in human plasma.3 It binds to cholera toxin when expressed in rat C6 glioma cultured cells, increasing intracellular cAMP to similar levels as cells expressing ganglioside GM1 .4 This product contains fucosylated ganglioside GM1 molecular species with primarily C22:0 and C24:0 fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1526]
1.Macher, B.A., Pacuszka, T., Mullin, B.R., et al.Isolation and identification of a fucose-containing ganglioside from bovine thyroid glandBiochim. Biophys. Acta588(1)35-43(1979) 2.Vangsted, A.J., and Zeuthen, J.Monoclonal antibodies for diagnosis and potential therapy of small cell lung cancer--the ganglioside antigen fucosyl-GM1Acta. Oncol.32(7-8)845-851(1993) 3.Vangsted, A.J., Clausen, H., Kjeldsen, T.B., et al.Immunochemical detection of a small cell lung cancer-associated ganglioside (FucGM1) antigen in serumCancer Res.51(11)2879-2884(1991) 4.Masserini, M., Freire, E., Calappi, E., et al.Fuc-GM1 ganglioside mimics the receptor function of GM1 for cholera toxinBiochemistry31(8)2422-2426(1992)
| Cas No. | SDF | Download SDF | |
| 别名 | Fucosylated Monosialoganglioside GM1, Fucosyl GM1 | ||
| Canonical SMILES | OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@]3([H])O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@@]4([H])[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O[C@@]5([H])O[C@H](C)[C@H](O)[C@H](O)[C@H]5O)O)CO)O[C@]6(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O6)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O.[NH4+] | ||
| 分子式 | C79H140N3O35 ? NH4 (for stearoyl) | 分子量 | 1710 |
| 溶解度 | Chloroform:Methanol:Water (2:1:0.1): Soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.5848 mL | 2.924 mL | 5.848 mL |
| 5 mM | 0.117 mL | 0.5848 mL | 1.1696 mL |
| 10 mM | 0.0585 mL | 0.2924 mL | 0.5848 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。