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Flurbiprofen Sale

(Synonyms: 氟比洛芬; dl-Flurbiprofen) 目录号 : GC16880

A non-selective COX inhibitor

Flurbiprofen Chemical Structure

Cas No.:5104-49-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥410.00
现货
100mg
¥357.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.Target: PGE synthaseFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. Flurbiprofen may have unique pharmacological properties that reduce the accumulation of unfolded proteins and may represent a new class of drug for the fundamental treatment of obesity [1]. Flurbiprofen and its enantiomers selectively lower Aβ42 levels in broken cell γ-secretase assays, indicating that these compounds directly target the γ-secretase complex that generates Aβ from APP. Of the compounds tested, meclofenamic acid, racemic flurbiprofen, and the purified R and S enantiomers of flurbiprofen lowered Aβ42 levels to the greatest extent [2].

References:
[1]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014.
[2]. Eriksen, J.L., et al., NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest, 2003. 112(3): p. 440-9.

Chemical Properties

Cas No. 5104-49-4 SDF
别名 氟比洛芬; dl-Flurbiprofen
化学名 2-(3-fluoro-4-phenylphenyl)propanoic acid
Canonical SMILES CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
分子式 C15H13FO2 分子量 244.26
溶解度 ≥ 11.35 mg/mL in DMSO, ≥ 51.2 mg/mL in EtOH 储存条件 Store at RT
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.094 mL 20.47 mL 40.94 mL
5 mM 0.8188 mL 4.094 mL 8.188 mL
10 mM 0.4094 mL 2.047 mL 4.094 mL
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