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Fludarabine triphosphate trisodium

目录号 : GC66430

Fludarabine triphosphate (F-ara-ATP) trisodium 是 Fludarabine 的活性代谢物,是一种有效的、非竞争性的、特异性的DNA引发酶 (DNA primase) 抑制剂,其 IC50 为 2.3 μM,Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA聚合酶,最终导致细胞凋亡 (apoptosis)。$

规格 价格 库存 购买数量
5mg
¥2,700.00
现货
10mg
¥4,320.00
现货
25mg
¥8,550.00
现货
100mg
¥27,000.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)[1]

Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine , is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2].

Fludarabine triphosphate trisodium is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells[1].
Fludarabine triphosphate trisodium (10-50 μM) inhibits the incorporation of ATP into primer RNA and dTTP into DNA to a similar extent[1].

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Chemical Properties

Cas No. N/A SDF Download SDF
别名 F-ara-ATP trisodium
化学名 N/A
Canonical SMILES N/A
分子式 C10H12FN5Na3O13P3 分子量 591.12
溶解度 H2O : 250 mg/mL (422.93 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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