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Fesoterodine Fumarate Sale

(Synonyms: 富马酸非索罗定) 目录号 : GC16087

A muscarinic acetylcholine receptor antagonist

Fesoterodine Fumarate Chemical Structure

Cas No.:286930-03-8

规格 价格 库存 购买数量
5mg
¥443.00
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10mg
¥621.00
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50mg
¥2,025.00
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1g
¥4,775.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist.IC50 value:Target: mAChRFesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.

References:
[1]. Staskin David; Khullar Vik; Michel Martin C et al. Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics (2011), 30(8), 1480-5.
[2]. Vella Maria; Cardozo Linda Review of fesoterodine. Expert opinion on drug safety (2011), 10(5), 805-8.
[3]. Malhotra Bimal; Alvey Christine; Gong Jason et al. Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology (2011), 72(2), 257-62.
[4]. Michel MC. Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert Opin Pharmacother. 2008 Jul;9(10):1787-96.
[5]. Fesoterodine

Chemical Properties

Cas No. 286930-03-8 SDF
别名 富马酸非索罗定
化学名 (E)-but-2-enedioic acid;[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
Canonical SMILES CC(C)C(=O)OC1=C(C=C(C=C1)CO)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2.C(=CC(=O)O)C(=O)O
分子式 C30H41NO7 分子量 527.65
溶解度 Methanol: Slightly Soluble,Water: Slightly Soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.8952 mL 9.476 mL 18.952 mL
5 mM 0.379 mL 1.8952 mL 3.7904 mL
10 mM 0.1895 mL 0.9476 mL 1.8952 mL
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