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Eptifibatide Sale

(Synonyms: 依替巴肽) 目录号 : GC52193

A potent GPIIb/IIIa antagonist

Eptifibatide Chemical Structure

Cas No.:188627-80-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥569.00
现货
5mg
¥383.00
现货
10mg
¥620.00
现货
25mg
¥1,298.00
现货
50mg
¥2,101.00
现货
100mg
¥3,368.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Eptifibatide is a potent glycoprotein IIb/IIIa antagonist (GPIIb/IIIa; Kd = 120 nM) that inhibits platelet aggregation.1,2 Eptifibatide prevents binding of the adhesion proteins fibrinogen and von Willebrand factor to GPIIb/IIIa on the surface of activated platelets to prevent aggregation and thrombus formation.3 It inhibits ADP-induced citrated blood aggregation (IC50 = 0.11-0.22 μg/ml) in vitro and in vivo (IC50 = 52 μg/ml in porcine plasma).1,4 Formulations containing eptifibatide have been used to reduce risk of thrombolysis in myocardial infarction in patients undergoing percutaneous coronary intervention.5

1.Harder, S., Klinkhardt, U., Graff, J., et al.In vitro dose response to different GPIIb/IIIa-antagonists: Inter-laboratory comparison of various platelet function testsThromb. Res.102(1)39-48(2001) 2.Moser, M., Bertram, U., Peter, K., et al.Abciximab, eptifibatide, and tirofiban exhibit dose-dependent potencies to dissolve platelet aggregatesJ. Cardiovasc. Pharmacol.41(4)586-592(2003) 3.Scarborough, R.M.Development of eptifibatideAm. Heart J.138(6 Pt 1)1093-1104(1999) 4.Ciborowski, M., and Tomasiak, M.The in vitro effect of eptifibatide, a glycoprotein IIb/IIIa antagonist, on various responses of porcine blood plateletsActa Pol. Pharm.66(3)235-242(2009) 5.Zhou, X., Wu, X., Sun, H., et al.Efficacy and safety of eptifibatide versus tirofiban in acute coronary syndrome patients: A systematic review and meta-analysisJ. Evid. Based Med.10(2)136-144(2017)

Chemical Properties

Cas No. 188627-80-7 SDF Download SDF
别名 依替巴肽
Canonical SMILES O=C([C@H](CC1=CNC2=C1C=CC=C2)N3)N4[C@](CCC4)([H])C(N[C@H](C(N)=O)CSSCCC(N[C@@H](CCCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C3=O)=O)=O)=O)=O
分子式 C35H49N11O9S2 分子量 832
溶解度 DMF: 30 mg/ml,DMSO: 14 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2019 mL 6.0096 mL 12.0192 mL
5 mM 0.2404 mL 1.2019 mL 2.4038 mL
10 mM 0.1202 mL 0.601 mL 1.2019 mL
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