Drospirenone-13C3
(Synonyms: 1,2-dihydro Spirorenone-13C3, ZK 30595-13C3) 目录号 : GC52420An internal standard for the quantification of drospirenone
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Drospirenone-13C3 is intended for use as an internal standard for the quantification of drospirenone by GC- or LC-MS. Drospirenone is a synthetic progestogen.1 In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously.2 Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone and luteinizing hormone (LH) in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.3
1.Pollow, K., Juchem, M., Elger, W., et al.Dihydrospirorenone (ZK30595): A novel synthetic progestagen - characterization of binding to different receptor proteinsContraception46(6)561-574(1992) 2.Muhn, P., Fuhrmann, U., Fritzemeier, K.-H., et al.Drospirenone: A novel progestogen with antimineralocorticoid and antiandrogenic activityAnn. N. Y. Acad. Sci.761(1)311-335(1995) 3.Apter, D., Zimmerman, Y., Beekman, L., et al.Bleeding pattern and cycle control with estetrol-containing combined oral contraceptives: Results from a phase II, randomised, dose-finding study (FIESTA)Contraception94(4)366-373(2016)
| Cas No. | SDF | Download SDF | |
| 别名 | 1,2-dihydro Spirorenone-13C3, ZK 30595-13C3 | ||
| Canonical SMILES | O=C1CC[C@@]2(C)C([C@@](C3)([H])[C@@]3([H])[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])[C@@](C6)([H])[C@@]6([H])[C@@]57[13CH2][13CH2][13C](O7)=O)=C1 | ||
| 分子式 | C21[13C]3H30O3 | 分子量 | 369.5 |
| 溶解度 | Acetonitrile: soluble,DMSO: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7064 mL | 13.5318 mL | 27.0636 mL |
| 5 mM | 0.5413 mL | 2.7064 mL | 5.4127 mL |
| 10 mM | 0.2706 mL | 1.3532 mL | 2.7064 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。