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Docosahexaenoic Acid 1,2,3,4-13C

(Synonyms: C22:6 n-3 1,2,3,4-13C, C22:6(4Z,7Z,10Z,13Z,16Z,19Z) 1,2,3,4-13C, Cervonic Acid 1,2,3,4-13C, DHA 1,2,3,4-13C) 目录号 : GC49590

An internal standard for the quantification of DHA

Docosahexaenoic Acid 1,2,3,4-13C Chemical Structure

规格 价格 库存 购买数量
25 µg
¥904.00
现货
50 µg
¥1,618.00
现货
100 µg
¥3,061.00
现货
250 µg
¥7,185.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Docosahexaenoic acid 1,2,3,4-13C (DHA 1,2,3,4-13C) is intended for use as an internal standard for the quantification of DHA by GC- or LC-MS. DHA is a long-chain ω-3 polyunsaturated fatty acid (PUFA) found in fish and algal oils.1 It comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes.2 DHA typically represents 0.52-7.5% of human total plasma fatty acids. It is produced from α-linolenic acid via a series of desaturase- and elongase-catalyzed reactions, resulting in a docosapentaenoic acid intermediate, which is elongated, desaturated, and β-oxidized to produce DHA.3 DHA can be liberated from cellular membranes by phospholipase A2 (PLA2) and converted to numerous oxylipins, including specialized pro-resolving mediators (SPMs), which are produced by lipoxygenases and include D-series protectins and resolvins, as well as maresins, that regulate host defense and the resolution of inflammation.4 DHA has roles in several physiological and pathological processes, including neural development, cardiovascular diseases, obesity, and inflammation.3,5

1.Kuratko, C.N., and Salem, N., Jr.Biomarkers of DHA statusProstaglandins Leukot. Essent. Fatty Acids81(2-3)111-118(2009) 2.Lacombe, R.J.S., Chouinard-Watkins, R., and Bazinet, R.P.Brain docosahexaenoic acid uptake and metabolismMol. Aspects Med.64109-134(2018) 3.Calder, P.C.Docosahexaenoic acidAnn. Nutr. Metab.69(Suppl 1)7-21(2016) 4.Basil, B.C., and Levy, B.D.Specialized pro-resolving mediators: Endogenous regulators of infection and inflammationNat. Rev. Immunol.16(1)51-67(2016) 5.Arnoldussen, I.A.C., and Kiliaan, A.J.Impact of DHA on metabolic diseases from womb to tombMar. Drugs12(12)6190-6212(2014)

Chemical Properties

Cas No. N/A SDF Download SDF
别名 C22:6 n-3 1,2,3,4-13C, C22:6(4Z,7Z,10Z,13Z,16Z,19Z) 1,2,3,4-13C, Cervonic Acid 1,2,3,4-13C, DHA 1,2,3,4-13C
Canonical SMILES CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=[13CH]\[13CH2][13CH2][13C](O)=O
分子式 C18[13C]4H32O2 分子量 332.5
溶解度 Ethanol: 2 mg/ml 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 3.0075 mL 15.0376 mL 30.0752 mL
5 mM 0.6015 mL 3.0075 mL 6.015 mL
10 mM 0.3008 mL 1.5038 mL 3.0075 mL
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