DK3
目录号 : GC63989
DK3 是一种有效选择性的雌激素相关受体 α (ERRα) 激动剂。
Cas No.:1187568-16-6
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
DK3 is a potent and selective estrogen-related receptor alpha (ERRα) agonist[1].
[1]. Lu G , et al. Subresidue-Resolution Footprinting of Ligand-Protein Interactions by Carbene Chemistry and Ion Mobility-Mass Spectrometry. Anal Chem. 2020;92(1):947-956.
| Cas No. | 1187568-16-6 | SDF | Download SDF |
| 分子式 | C16H14N2O2 | 分子量 | 266.29 |
| 溶解度 | DMSO : 12.5 mg/mL (46.94 mM; ultrasonic and warming and heat to 60°C) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7553 mL | 18.7765 mL | 37.553 mL |
| 5 mM | 0.7511 mL | 3.7553 mL | 7.5106 mL |
| 10 mM | 0.3755 mL | 1.8777 mL | 3.7553 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Genome sequencing and characterization of three Bacillus cereus-specific phages, DK1, DK2, and DK3
Arch Virol 2019 Jul;164(7):1927-1929.PMID:31011817DOI:10.1007/s00705-019-04258-1.
In the study, three Bacillus cereus-specific phages, named DK1, DK2 and DK3, belonging to the family Podoviridae, were isolated from Pearl River water and sludge in Guangzhou, China. The genomes of DK1, DK2 and DK3 were 27,180 bp, 26,357 bp, and 26,865 bp in length and contained 49, 45 and 46 open reading frames, respectively. Among the three phages, DK2 shared the highest genome sequence similarity (96% identity) with DK3. Genes encoding rRNA, tRNA, virulence factors and antibiotic resistance were absent in these phage genomes. In addition, comparative genomic and phylogenetic analysis revealed that they were novel phages of B. cereus. Each genome encoded a putative endolysin that might be of value for the control of the foodborne pathogen B. cereus.
Complete nucleotide sequence of double-stranded RNA viruses from Fusarium graminearum strain DK3
Arch Virol 2009;154(11):1855-8.PMID:19777156DOI:10.1007/s00705-009-0507-5.
The complete genomes two different dsRNA mycoviruses, Fusarium graminearum virus 3 (FgV3) and Fusarium graminearum virus 4 (FgV4), was sequenced and analyzed. The viral genome of FgV3 is 9,098 base pairs (bp) long and contains two open reading frames (ORF) encoding a putative RNA-dependent RNA polymerase (RdRp) and a protein of unknown function. The FgV4 genome is composed of two dsRNA genome segments of 2,383 bp and 1,739 bp. FgV4 dsRNA-1 contains a single ORF, which has a conserved RdRp motif, while FgV4 dsRNA-2 contains two putative ORFs coding for products of unknown function. Both the genome organization and phylogenetic analysis indicated that FgV3 was closely related to members of the families Totiviriridae and Chrysoviridae, but it was placed outside of their main clusters, whereas FgV4 formed a distinct clade with the family Partitiviridae. This is the first report of the full-length nucleotide sequences of FgV3 and FgV4 infecting Fusarium graminearum.
Theoretical study of valence photoelectron spectra of Re(CO)5X (X=Cl, Br, and I): a spin-orbit DK3 symmetry-adapted cluster/symmetry-adapted cluster-configuration interaction study
J Chem Phys 2006 Jun 14;124(22):224307.PMID:16784274DOI:10.1063/1.2206186.
The valence photoelectron spectra of Re(CO)(5)X (X=Cl, Br, and I) are studied theoretically using symmetry-adapted cluster (SAC)/SAC-configuration interaction (SAC-CI) theory. The relativistic effects are included by the third-order Douglas-Kroll (DK3) method, and the spin-orbit coupling is also considered. Both electron correlation and relativistic effects are significant in assigning the valence photoelectron spectra of Re(CO)(5)X (X=Cl, Br, and I). DK3-SAC/SAC-CI provides values for the relative peak positions in a reasonable agreement with the observed photoelectron spectra. The sequence of ionization energies for Re(CO)(5)Cl, Re(CO)(5)Br, and Re(CO)(5)I are calculated as e(')[a(1)(Cl)]>e(')[e(Re+Cl)] approximately e(")[e(Re+Cl)]>e(")[b(2)(Re)]>e(')[e(Re-Cl)]>e(")[e(Re-Cl)], e(')[a(1)(Br)]>e(')[e(Re+Br)]>e(")[e(Re+Br)+b(2)(Re)]>e(")[b(2)(Re)+e(Re+Br)]>e(')[e(Re-Br)]>e(")[e(Re-Br)], and e(')[e(Re+I)+a(1)(I)]>e(")[b(2)(Re)+e(Re+I)] approximately e(')[a(1)(I)+e(Re+I)]>e(")[e(Re+I)+b(2)(Re)]>e(')[e(Re-I)]>e(")[e(Re-I)], respectively. These assignments are quite new and different from previous assignments.
Correlation consistent basis sets for actinides. I. The Th and U atoms
J Chem Phys 2015 Feb 21;142(7):074105.PMID:25702000DOI:10.1063/1.4907596.
New correlation consistent basis sets based on both pseudopotential (PP) and all-electron Douglas-Kroll-Hess (DKH) Hamiltonians have been developed from double- to quadruple-zeta quality for the actinide atoms thorium and uranium. Sets for valence electron correlation (5f6s6p6d), cc - pV nZ - PP and cc - pV nZ - DK3, as well as outer-core correlation (valence + 5s5p5d), cc - pwCV nZ - PP and cc - pwCV nZ - DK3, are reported (n = D, T, Q). The -PP sets are constructed in conjunction with small-core, 60-electron PPs, while the -DK3 sets utilized the 3rd-order Douglas-Kroll-Hess scalar relativistic Hamiltonian. Both series of basis sets show systematic convergence towards the complete basis set limit, both at the Hartree-Fock and correlated levels of theory, making them amenable to standard basis set extrapolation techniques. To assess the utility of the new basis sets, extensive coupled cluster composite thermochemistry calculations of ThFn (n = 2 - 4), ThO2, and UFn (n = 4 - 6) have been carried out. After accurately accounting for valence and outer-core correlation, spin-orbit coupling, and even Lamb shift effects, the final 298 K atomization enthalpies of ThF4, ThF3, ThF2, and ThO2 are all within their experimental uncertainties. Bond dissociation energies of ThF4 and ThF3, as well as UF6 and UF5, were similarly accurate. The derived enthalpies of formation for these species also showed a very satisfactory agreement with experiment, demonstrating that the new basis sets allow for the use of accurate composite schemes just as in molecular systems composed only of lighter atoms. The differences between the PP and DK3 approaches were found to increase with the change in formal oxidation state on the actinide atom, approaching 5-6 kcal/mol for the atomization enthalpies of ThF4 and ThO2. The DKH3 atomization energy of ThO2 was calculated to be smaller than the DKH2 value by ∼1 kcal/mol.
A barotolerant ciliate isolated from the abyssal deep sea of the North Atlantic: Euplotes dominicanus sp. n. (Ciliophora, Euplotia)
Eur J Protistol 2020 Apr;73:125664.PMID:31978632DOI:10.1016/j.ejop.2019.125664.
A new Euplotes species, isolated from abyssal depths (>4000 m) of the North Atlantic Ocean, was described based on morphology, ciliary pattern and molecular data. Euplotes dominicanus sp. n. is characterized by a small body size (29-40 × 17-27 μm in vivo), 18-22 adoral membranelles, 10 frontoventral, five transverse and two left marginal cirri and one caudal cirrus, five or six dorsolateral kineties with 7-9 dikinetids in mid-dorsolateral kinety (DK3), and dorsal silverline system of the double-eurystomus type. Phylogenetic analyses inferred from 18S rRNA sequences show that Euplotes dominicanus sp. n. is most closely related to E. curdsi, with a sequence similarity of 97.6 %. Euplotes dominicanus sp. n. was able to survive hydrostatic pressures up to 500 bar indicating its barotolerance. Metabarcoding data demonstrate the presence of E. dominicanus sp. n. in sediments of several deep-sea basins.