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Digitonin 目录号 GC32854

Digitonin是从洋地黄中提取的糖苷,可通过与胆固醇分子结合来增加细胞膜的通透性,并能抑制肿瘤生长

规格 价格 库存 购买数量
10 mM * 1 mL in Water
¥491.00
现货
25mg
¥446.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 11024-24-1 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])[C@@H](O)[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(C[C@@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@@](O[C@H](CO)[C@H
分子式 C₅₆H₉₂O₂₉ 分子量 1229.31
溶解度 H2O : 50 mg/mL (40.67 mM; Need ultrasonic) 储存条件 Store at 4°C, stored under nitrogen
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth.

Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro[1].

In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg[1].

Reference:

[1]. Lindnér PG, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol. 1997;40(5):444-8.