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Desipramine hydrochloride Sale

(Synonyms: 盐酸去甲咪嗪;盐酸地昔帕明) 目录号 : GC10126

Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET)、5-HT 转运蛋白 (SERT) 和多巴胺转运蛋白 (DAT) 的抑制剂,Kis 分别为 4、61 和 78,720 nM。

Desipramine hydrochloride Chemical Structure

Cas No.:58-28-6

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50mg
¥588.00
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实验参考方法

Animal experiment:

Rats are anesthetized with ketamine (100 mg/kg) and xylazine (10 mg/kg) and implanted subcutaneously with osmotic minipumps preloaded with either vehicle (50% saline, 40% DMSO, and 10% ethanol) or Desipramine hydrochloride at a concentration that delivered 5, 10, or 15 mg/kg per day of the free base. Minipumps are removed, under anesthesia, 14 days later. Rats are tested for antidepressant-like behavior in the forced-swim test 2 to 8 days after pump removal and discontinuation of Desipramine hydrochloride treatment. Following the completion of the behavioral tests, rats are killed by decapitation, their brains are removed, and cerebral cortex and hippocampus are dissected for neurochemical analyses[2].

References:

[1]. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25.
[2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.

产品描述

Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.

Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay)[2].

References:
[1]. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25.
[2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.

Chemical Properties

Cas No. 58-28-6 SDF
别名 盐酸去甲咪嗪;盐酸地昔帕明
化学名 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine hydrochloride
Canonical SMILES CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C13.Cl
分子式 C18H22N2.HCl 分子量 302.84
溶解度 ≥ 119.6mg/mL in DMSO 储存条件 Store at 2-8°C
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1 mM 3.3021 mL 16.5104 mL 33.0207 mL
5 mM 0.6604 mL 3.3021 mL 6.6041 mL
10 mM 0.3302 mL 1.651 mL 3.3021 mL
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