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CXCR2-IN-1 Sale

目录号 : GC31754

CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂,pIC50值为9.3。

CXCR2-IN-1 Chemical Structure

Cas No.:1873376-49-8

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥3,274.00
现货
1mg
¥1,339.00
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5mg
¥3,124.00
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10mg
¥5,355.00
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25mg
¥10,710.00
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50mg
¥17,404.00
现货
100mg
¥30,345.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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实验参考方法

Animal experiment:

Mice: Mice are fed with cuprizone for 5 weeks to cause demyelinating lesions in the CNS and then orally administrated with CXCR2-IN-1 for 9 consecutive days at doses of 30 and 100 mg/kg twice daily[1].

References:

[1]. Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

产品描述

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)[1].

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].

[1]. Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.

Chemical Properties

Cas No. 1873376-49-8 SDF
Canonical SMILES ClC1=CC=C(NC(NC2=CC=CC(F)=C2Cl)=O)C(O)=C1S(=O)(C3CCN(C)CC3)=O
分子式 C19H20Cl2FN3O4S 分子量 476.35
溶解度 DMSO : 5.4 mg/mL (11.34 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0993 mL 10.4965 mL 20.993 mL
5 mM 0.4199 mL 2.0993 mL 4.1986 mL
10 mM 0.2099 mL 1.0496 mL 2.0993 mL
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