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CU-CPD107

目录号 : GC25314

CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. 

CU-CPD107 Chemical Structure

Cas No.:2573912-32-8

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5mg
¥1,548.00
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25mg
¥4,716.00
现货

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产品描述

CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.

CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1]

[1] Yang Y, et al. Nat Commun. 2021 Jul 16;12(1):4351.

Chemical Properties

Cas No. 2573912-32-8 SDF Download SDF
分子式 C16H21IN2O2 分子量 400.26
溶解度 DMSO: 80 mg/mL (199.87 mM);Water: Insoluble;Ethanol: 80 mg/mL (199.87 mM) 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4984 mL 12.4919 mL 24.9838 mL
5 mM 0.4997 mL 2.4984 mL 4.9968 mL
10 mM 0.2498 mL 1.2492 mL 2.4984 mL
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Research Update

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Nat Commun 2021 Jul 16;12(1):4351.PMID:34272380DOI:PMC8285539

Small-molecule modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clinical uses are limited because they can invoke an uncontrolled, global inflammatory response. The efforts described herein culminate in the fortuitous discovery of a tetrasubstituted imidazole CU-CPD107 which inhibits R848-induced TLR8 signaling. In stark contrast, CU-CPD107 shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling. CU-CPD107's unique, dichotomous behavior sheds light on a way to approach TLR agonists. CU-CPD107 offers the opportunity to avoid the undesired, global inflammation side effects that have rendered imidazoquinolines clinically irrelevant, providing an insight for the development of antiviral drugs.