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Compound 48/80 (hydrochloride) 目录号 GC43305

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50mg
¥585.00
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100mg
¥1,118.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 848035-21-2 SDF Download SDF
别名 N/A
化学名 4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine, trihydrochloride
Canonical SMILES COC1=CC=C(CCNC)C=C1CC2=CC(CCNC)=CC(CC3=C(OC)C=CC(CCNC)=C3)=C2OC.Cl.Cl.Cl
分子式 C32H45N3O33HCl 分子量 629.1
溶解度 100mM in water 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Compound 48/80 is a condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde that causes histamine degranulation from mast cells.[1] Compound 48/80 also inhibits human platelet aggregation through suppression of calmodulin (CaM) (IC50 = 0.41 μg/ml for CaM-dependent Ca2+-transporter ATPase activity) and phospholipase C (IC50s = 2.1 and 5.0 μg/ml for cytosolic and particulate phosphatidylinositol-specific activities, respectively).[2],[3]

Reference:
[1]. Rothschild, A.M. Mechanisms of histamine release by compound 48/80. Br. J. Pharmac. 38(1), 253-262 (1970).
[2]. Adamczyk-Engelmann, P., and Gietzen, K. Induction of histamine release and calmodulin antagonism are two distinct properties of compound 48/80. Cell Calcium 10(2), 93-99 (1989).
[3]. Bronner, C., Charles, W., Didier, M., et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys. Acta. 920(3), 301-305 (1987).