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Cletoquine oxalate Sale

(Synonyms: 氯托喹草酸,Desethylhydroxychloroquine oxalate) 目录号 : GC60715

Cletoquineoxalate(Desethylhydroxychloroquineoxalate)是Hydroxychloroquine的主要活性代谢产物,是由CYP2D6,CYP3A4,CYP3A5和CYP2C8同工酶在肝脏中形成的。Cletoquineoxalate也是一种Chloroquine衍生物,具有抗基孔肯雅热病毒(CHIKV)的能力。Cletoquineoxalate具有抗疟作用,并可用于自身免疫性疾病的研究。

Cletoquine oxalate Chemical Structure

Cas No.:14142-64-4

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1mg
¥2,520.00
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5mg
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10mg
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50mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3].

[1]. Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120(10):18298-18308. [2]. Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32(8):e4258. [3]. Chhonker YS, et al. Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC-ESI-MS/MS: An application for pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:320-327.

Chemical Properties

Cas No. 14142-64-4 SDF
别名 氯托喹草酸,Desethylhydroxychloroquine oxalate
Canonical SMILES CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCCO.O=C(O)C(O)=O
分子式 C18H24ClN3O5 分子量 397.85
溶解度 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.5135 mL 12.5676 mL 25.1351 mL
5 mM 0.5027 mL 2.5135 mL 5.027 mL
10 mM 0.2514 mL 1.2568 mL 2.5135 mL
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