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Cladribine Sale

(Synonyms: 克拉屈滨; 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA) 目录号 : GC10509

A nucleoside analog and prodrug form of 2-CdATP

Cladribine Chemical Structure

Cas No.:4291-63-8

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥399.00
现货
5mg
¥389.00
现货
25mg
¥546.00
现货
100mg
¥1,061.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Cladribine is an adenosine deaminase inhibitor.Adenosine deaminase is an enzyme that involved in purine metabolism.
Cladribine is a well-known purine nucleoside analog with particular activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL). In U266, RPMI8226 and MM1.S cells, Cladribine inhibited cell proliferation in a dose-dependant way with IC50 value of 2.43, 0.75 and 0.18 μmol/L, respectively. Apoptosis assays showed that Cladribine induced apoptosis of U266, RPMI8226 and MM1.S cells in a dose-dependant way [1]. In MM1.S cells, Cladribine (0.2uM) induces activation of caspase-3, -8, and -9 and PARP cleavage in a time-dependent way and reduces the phospho-STAT3 levels in a dose-dependent way. Also, Cladribine induces accumulation of DNA strand breaks and then activates the tumor suppressor p53 in lymphocytes [1].
In the treatment of indolent lymphoid malignancies, lower doses of Cladribine (5 mg/m2/week) are highly active and possibly better tolerated than standard doses [2].
References:
[1]. Ma J, Wang S, Zhao M, et al. Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer, 2011, 11: 255.
[2]. Robak T, Korycka A, Robak E. Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat Anticancer Drug Discov, 2006, 1(1): 23-38.

Chemical Properties

Cas No. 4291-63-8 SDF
别名 克拉屈滨; 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA
化学名 (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
Canonical SMILES C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O
分子式 C10H12ClN5O3 分子量 285.69
溶解度 ≥ 41.7mg/mL in DMSO with gentle warming 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5003 mL 17.5015 mL 35.003 mL
5 mM 0.7001 mL 3.5003 mL 7.0006 mL
10 mM 0.35 mL 1.7501 mL 3.5003 mL
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