Chlorobutanol hemihydrate
(Synonyms: 三氯叔丁醇半水合物) 目录号 : GC62358
Chlorobutanol hemihydrate 是一种药物防腐剂，具有镇静催眠作用。Chlorobutanol hemihydrate 对多种革兰氏阳性和革兰氏阴性细菌 ( Gram-positive and Gram-negative bacteria) 以及几种霉菌孢子和真菌 (fungi) 具有抗性，广泛用于食品和化妆品工业。
Cas No.:6001-64-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chlorobutanol hemihydrate is a pharmaceutical preservative with sedative-hypnotic actions. Chlorobutanol hemihydrate is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol hemihydrate is widely used in food and cosmetic industry[1][2].
[1]. Smoak IW, et al. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997 Oct;39(5):287-90.
[2]. Friesen WT, et al. The antibacterial stability of chlorobutanol stored in polyethylene bottles. Am J Hosp Pharm. 1971 Jul;28(7):507-12.
| Cas No. | 6001-64-5 | SDF | |
| 别名 | 三氯叔丁醇半水合物 | ||
| 分子式 | C4H7Cl3O.1/2H2O | 分子量 | 186.46 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.3631 mL | 26.8154 mL | 53.6308 mL |
| 5 mM | 1.0726 mL | 5.3631 mL | 10.7262 mL |
| 10 mM | 0.5363 mL | 2.6815 mL | 5.3631 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Preparation of dry reconstituted liposomal powder by freeze-drying at room temperature
J Liposome Res 2011 Mar;21(1):28-37.PMID:20387991DOI:10.3109/08982101003735970.
The aim of this study was to develop a novel, one-step method of liposome preparation by freeze-drying at room temperature as well as to investigate the physicochemical properties of dry reconstituted liposomal powder that was prepared. The method was based on utilizing sublimation of a volatile solid inert carrier, that is, Chlorobutanol hemihydrate (CBN), instead of ice, which was less sophisticated and simpler than the conventional freeze-drying process. The optimum conditions used in the sublimation process of CBN were a temperature of 25-30°C and a pressure of 1.5-2.0 mBar for 8 hours. The influence of various parameters, such as type, particle size, and ratio of sugar lyoprotectant (i.e., mannitol or sucrose) and CBN to lipid on reconstitution time, liposome size, zeta potential, vesicle type, and lamella structure of reconstituted liposomes, were studied. The results revealed that the obtained liposomes were oligolamellar vesicles with particle sizes ranging from 400 to 1,000 nm. Type and ratio of sugar and CBN to lipid were found to significantly affect the reconstitution time. On the other hand, liposome size was independent of type of sugar and ratio of CBN to lipid, yet became smaller at higher sugar-to-lipid ratio and smaller sugar and CBN size. In all cases, traces of residual solvents were definitely below the acceptable limit.