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Memantine hydrochloride Sale

(Synonyms: 盐酸美金刚; D-145 hydrochloride) 目录号 : GC10198

An NMDA receptor antagonist

Memantine hydrochloride Chemical Structure

Cas No.:41100-52-1

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10mM (in 1mL DMSO)
¥350.00
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500mg
¥280.00
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1g
¥396.00
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5g
¥693.00
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产品描述

Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93μM, 0.82μM and 0.47μM for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].

Memantine is an uncompetitive NMDA receptor antagonist. When using HEK293 cells express recombinant rat NMDA receptors, memantine shows inhibition of L-glutamate-mediated response with a dose- and voltage-dependent manner. Memantine also has a rapid unblocking kinetics [1].

Memantine is used clinically in spasticity, Parkinson's disease and Alzheimer’s disease. Memantine is found to attenuate the deleterious action of Aβ in the in vitro numerous studies. It is probably due to the decreased tau phosphorylation caused by memantine [2].

References:
[1] Bresink I, Benke T A, Collett V J, et al. Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. British journal of pharmacology, 1996, 119(2): 195-204.
[2] Danysz W, Parsons C G. Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine–searching for the connections. British journal of pharmacology, 2012, 167(2): 324-352.

Chemical Properties

Cas No. 41100-52-1 SDF
别名 盐酸美金刚; D-145 hydrochloride
化学名 3,5-dimethyladamantan-1-amine;hydrochloride
Canonical SMILES CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
分子式 C12H22ClN 分子量 215.76
溶解度 ≥ 12.6mg/mL in DMSO; ≥20 mg/mL in Water 储存条件 Store at RT
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1 mg 5 mg 10 mg
1 mM 4.6348 mL 23.1739 mL 46.3478 mL
5 mM 0.927 mL 4.6348 mL 9.2696 mL
10 mM 0.4635 mL 2.3174 mL 4.6348 mL
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