Cabotegravir sodium
(Synonyms: 卡博特韦钠; GSK-1265744 sodium; S/GSK1265744 sodium) 目录号 : GC66051An HIV-1 integrase inhibitor
Sample solution is provided at 25 µL, 10mM.
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Cabotegravir is an inhibitor of HIV-1 integrase (IC50 = 3 nM in a strand transfer assay).1 It inhibits HIV replication in MT-4 cells and peripheral blood mononuclear cells (PBMCs; IC50s = 1.3 and 0.2 nM, respectively). Cabotegravir (50 mg/kg) is protective against simian/human immunodeficiency virus (SHIV) infection in macaques when administered 1 week prior to viral challenge.2
1.Johns, B.A., Kawasuji, T., Weatherhead, J.G., et al.Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).J. Med. Chem.56(14)5901-5916(2013) 2.Andrews, C.D., Spreen, W.R., Mohri, H., et al.Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virusScience343(6175)1151-1154(2014)
| Cas No. | 1051375-13-3 | SDF | Download SDF |
| 别名 | 卡博特韦钠; GSK-1265744 sodium; S/GSK1265744 sodium | ||
| 分子式 | C19H16F2N3NaO5 | 分子量 | 427.33 |
| 溶解度 | DMSO : 6.9 mg/mL (16.15 mM; ultrasonic and warming and heat to 60°C) | 储存条件 | 4°C, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % ddH2O | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH2O，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。