C4 Human
目录号 : GP26223Human Complement C4 produced in Human plasma having a molecular mass of 205 kDa
Sample solution is provided at 25 µL, 10mM.
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Human Complement C4 produced in Human plasma having a molecular mass of 205 kDa.
| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Human Plasma. |
| Phycical Appearance | Sterile filtered solution. | Shipping Condition | withIcePacks |
| Synonyms | Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A, CO4, CPAMD2. | ||
| Stability | C4 Human is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | C4 protein solution contains 10mM sodium phosphate and 145mM NaCl, pH 7.3. | ||
Native human C4 is aglycosylated polypeptide containing 3 disulfide-linked chains. C4 is essential to the activation of both thelectin and the classical pathways of complement activation.Initiation of each pathway generates proteolytic enzyme complexes which are bound to the target surface. These enzymes cleave a peptide bond in C4 releasing the anaphylatoxin C4a and activating C4b. Like C3, the thioester of metastable C4b is highly reactive and is capable of reacting and covalently coupling C4b to amino or hydroxyl groups on the target surface. C4A and C4B are 2 variants of C4 that are common in manwhereas, in animals who have only 1 type usually have C4B.
C4 Human is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.