C1S Human
目录号 : GP26132Human Complement C1s produced in Human plasma having a molecular mass of 86 kDa
Sample solution is provided at 25 µL, 10mM.
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Human Complement C1s produced in Human plasma having a molecular mass of 86 kDa.
| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Human Plasma. |
| Phycical Appearance | Sterile Filtered solution. | Shipping Condition | withIcePacks |
| Synonyms | Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s, C1S. | ||
| Stability | Human C1s is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | The protein contains PBS. | ||
C1s enzyme (a subunit of the C1 complex) is the activated form of C1s proenzyme which is the first complement component in the classical pathway of complement. C1s proenzyme is an inactive zymogen until C1 is activated. C1 is a non-covalent calcium-dependent complex containing1 C1q, 2 C1r and 2 C1s molecules.The binding of multiple arms to immune complexes causesthe production of 2 proteases that cleave and activate the 2 C1s protease zymogens in the complex by the C1r proteins. This activation of C1s proenzyme results in its cleavage into 2 C1s chains of 58,000 and 28,000 Dalton.
Human C1s is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.