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C1R Human

目录号 : GP26131

Human Complement C1r produced in Human plasma having a molecular mass of 92 kDa

C1R Human Chemical Structure

规格 价格 库存 购买数量
20μg
¥2,800.00
现货
100μg
¥8,400.00
现货
1mg
¥42,000.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Human Complement C1r produced in Human plasma having a molecular mass of 92 kDa.

Product Data

Purity Greater than 90.0% as determined by SDS-PAGE. Source Human Plasma.
Phycical Appearance Sterile Filtered solution. Shipping Condition withIcePacks
Synonyms Complement C1r subcomponent, Complement component 1 subcomponent r, C1R.
Stability Human C1r is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles
Formulation 140mM NaCl, 10mM Imidazole and 2mM EDTA, pH 7.4.

Introduction

C1r enzyme is the activated form of C1r proenzyme which is inactive zymogen until C1 is activated.C1r is a subunit of the C1 complex which is the first complement component in the classical pathway of complement. C1 is a non-covalent calcium-dependent complex containing1 C1q, 2 C1r and 2 C1s molecules.Each C1q bindsthe Fc domains of IgG or IgM by using2 or more of its six arms. The binding of multiple arms to immune complexes causesthe production of 2 proteases that cleave and activate the 2 C1s protease zymogens in the complex by the C1r proteins. The activation of C1r results from cleavage of C1r into 2 fragments of 57,000 and 35,000 Dalton.

Stability

Human C1r is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles