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C18 Ganglioside GD3-d3 (ammonium salt) Sale

(Synonyms: Disialosyllactosylceramide-d3, N-omega-CD3-Octadecanoyl Disialoganglioside GD3-d3) 目录号 : GC49806

An internal standard for the quantification of ganglioside GD3

C18 Ganglioside GD3-d3 (ammonium salt) Chemical Structure

Cas No.:2692624-24-9

规格 价格 库存 购买数量
500 µg
¥9,438.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

C18 Ganglioside GD3-d3 is intended for use as an internal standard in the quantification of ganglioside GD3 by GC- or LC-MS. Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.1 Furthermore, the intracellular accumulation of ganglioside GD3 can contribute to mitochondrial damage, a crucial event during apoptosis.2 Ganglioside GD3 has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.1,3 [Matreya, LLC. Catalog No. 2054]

1.Hamamura, K., Furukawa, K., Hayashi, T., et al.Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cellsProc. Natl. Acad. Sci. USA102(31)11041-11046(2005) 2.De Maria, R., Lenti, L., Malisan, F., et al.Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosisScience277(5332)1652-1655(1997) 3.Nicoll, G., Avril, T., Lock, K., et al.Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanismsEur. J. Immunol.33(6)1642-1648(2003)

Chemical Properties

Cas No. 2692624-24-9 SDF Download SDF
别名 Disialosyllactosylceramide-d3, N-omega-CD3-Octadecanoyl Disialoganglioside GD3-d3
Canonical SMILES OC[C@H]1O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@H](O)[C@@H](O)[C@@H]1O[C@]2([H])O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O[C@@]4(C([O-])=O)O[C@@H]([C@H](O)[C@@H](CO)O)[C@H](NC(C)=O)[C@@H](O)C4)CO)[C@H](NC(C)=O)[C@@H](O)C3)[C@H]2O.[NH4+].[NH4+]
分子式 C70H120D3N3O29 • 2NH4 分子量 1509.8
溶解度 Chloroform:Methanol:Water (2:1:0.1): Soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.6623 mL 3.3117 mL 6.6234 mL
5 mM 0.1325 mL 0.6623 mL 1.3247 mL
10 mM 0.0662 mL 0.3312 mL 0.6623 mL
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