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BRD7116 Sale

目录号 : GC12811

A selective inhibitor of leukemia stem cells

BRD7116 Chemical Structure

Cas No.:329059-55-4

规格 价格 库存 购买数量
5mg
¥515.00
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10mg
¥882.00
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25mg
¥2,058.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

BRD7116, a bis-aryl sufone, acts as a selective inhibitor of leukemia stem cell activity by directly acting on the stromal cells to inhibit cobblestone formation [1,2].

BRD7116 displayed cell-non-autonomous anti-leukemia activity. In leukemia stem cells isolated from the bone marrow of leukemic animals in co-culture, BRD7116 exhibited an EC50 of 200 nM. BRD7116 displayed limited activity against normal HSPCs and AML cell lines with EC50s about 20 μM. BRD7116 showed activity against patient-derived primary human leukemia cells. Treatment of LSCe cells with BRD7116 induced transcriptional changes. The mechanism by which BRD7116 impaired the stroma’s ability to support leukemia cells has remained an important issue for future determination [1].

References:
[1] Hartwell K A, Miller P G, Mukherjee S, et al.  Niche-based screening identifies small-molecule inhibitors of leukemia stem cells[J]. Nature chemical biology, 2013, 9(12): 840-848.
[2] Sachlos E, Kerstetter-Fogle A.  Research Highlights: Highlights from the latest articles in regenerative medicine[J]. Regenerative medicine, 2014, 9(2): 145-147.

Chemical Properties

Cas No. 329059-55-4 SDF
化学名 N,N'-(sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
Canonical SMILES O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)=O
分子式 C28H36N2O4S 分子量 496.7
溶解度 ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0133 mL 10.0664 mL 20.1329 mL
5 mM 0.4027 mL 2.0133 mL 4.0266 mL
10 mM 0.2013 mL 1.0066 mL 2.0133 mL
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